Anti-urolithiatic effects of Punica granatum in male rats

In Ayurvedic medicine, the Punica granatum is considered “a Pharmacy unto itself”. In the present study we found that the chloroform and methanol extract of Punica granatum fruits has a role in preventing Urolithiasis in male rats. The traditional use of Punica granatum has been reported to regulate...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2012-03, Vol.140 (2), p.234-238
Main Authors: Rathod, N.R., Biswas, Dipak, Chitme, H.R., Ratna, Sanjeev, Muchandi, I.S., Chandra, Ramesh
Format: Article
Language:English
Subjects:
alkanes
animal models
Animals
calcium
Calcium - urine
calcium oxalate
Calcium Oxalate - urine
chloroform
creatinine
Creatinine - blood
Cystone
drinking water
Ethylene Glycol
histopathology
Kidney - drug effects
Kidney - metabolism
Kidney - pathology
Kidney Calculi - metabolism
Kidney Calculi - pathology
Kidney Calculi - prevention & control
kidneys
Male
methanol
Oxalates - metabolism
Phosphates - urine
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
prescribed burning
Punica granatum
Punicaceae
Rats
Rats, Wistar
sensation
tissue repair
urea
Urea - blood
uric acid
Uric Acid - blood
urine
Urolithiasis
Urolithiasis - metabolism
Urolithiasis - pathology
Urolithiasis - prevention & control
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Summary:In Ayurvedic medicine, the Punica granatum is considered “a Pharmacy unto itself”. In the present study we found that the chloroform and methanol extract of Punica granatum fruits has a role in preventing Urolithiasis in male rats. The traditional use of Punica granatum has been reported to regulate urine discharge and controls the burning sensation of urine. Animals model of calcium oxalate urolithiasis was developed in male rats by adding ethylene glycol 0.75% in drinking water. The Punica granatum chloroform extract (PGCE) and Punica grantum methanol extract (PGME) orally at 100, 200 and 400mg/kg, respectively, were administered along with ethylene glycol for 28 days. On 28 day, 24h urine was collected from individual rats and used for estimation of urine calcium, phosphate and oxalate. The serum creatinine, urea and uric acid levels were estimated in each animal. The kidney homogenate was used for the estimation of renal oxalate contents. The paraffin kidney sections were prepared to observe the CaOx deposits. The ethylene glycol control (Gr.-II) had significant (P
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2012.01.003