Determinants of early inadequate vancomycin concentrations during continuous infusion in septic patients

Abstract Vancomycin is frequently administered to critically ill patients by continuous infusion in order to optimise drug efficacy; however, there are few data available on the efficacy of this strategy in septic patients. In this retrospective analysis, 261 patients treated with continuous infusio...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2012-04, Vol.39 (4), p.332-337
Main Authors: Ocampos-Martinez, Eva, Penaccini, Laura, Scolletta, Sabino, Abdelhadii, Ali, Devigili, Alessandro, Cianferoni, Silvia, de Backer, Daniel, Jacobs, Frédérique, Cotton, Frédéric, Vincent, Jean-Louis, Taccone, Fabio Silvio
Format: Article
Language:English
Subjects:
Aged
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacokinetics
Anti-Bacterial Agents - therapeutic use
Antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Area Under Curve
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
Cohort Studies
confidence interval
Continuous infusion
creatinine
Creatinine - urine
Critically ill
drugs
Female
Human bacterial diseases
Humans
ICU
Infectious Disease
Infectious diseases
Infusions, Parenteral
Intensive Care Units
Male
Medical sciences
men
Middle Aged
patients
Pharmacokinetics
Pharmacology. Drug treatments
Predictive Value of Tests
regression analysis
Retrospective Studies
ROC Curve
Sepsis
Sepsis - blood
Sepsis - drug therapy
Sepsis - etiology
Severity of Illness Index
surface area
therapeutics
Time Factors
urine
Vancomycin
Vancomycin - administration & dosage
Vancomycin - pharmacokinetics
Vancomycin - standards
Vancomycin - therapeutic use
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Summary:Abstract Vancomycin is frequently administered to critically ill patients by continuous infusion in order to optimise drug efficacy; however, there are few data available on the efficacy of this strategy in septic patients. In this retrospective analysis, 261 patients treated with continuous infusion of vancomycin in the Department of Intensive Care at Hôpital Erasme (Brussels, Belgium) were evaluated. Creatinine clearance (CLCr ) was calculated from 24-h urine collection and normalised to body surface area. During the study period, 139 patients (53%) had insufficient vancomycin concentrations ( 120 mL/min/1.73 m2 had a sensitivity of 26%, a specificity of 94% and an 84% positive predictive value of 84% for vancomycin concentrations
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2011.12.008