Modulation of Leptin Resistance by Protein Tyrosine Phosphatases

Leptin plays a central role in weight control by suppressing food intake and increasing energy expenditure. The concept of leptin resistance emerged to explain the seemingly paradoxical elevated leptin levels in obesity. Recent discoveries reveal that protein tyrosine phosphatases are key players in...

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Bibliographic Details
Published in:Cell metabolism 2012-03, Vol.15 (3), p.292-297
Main Authors: St-Pierre, Julie, Tremblay, Michel L.
Format: Article
Language:English
Subjects:
Animals
Eating - genetics
Eating - physiology
Energy Metabolism - genetics
Energy Metabolism - physiology
Humans
Leptin - metabolism
Protein Tyrosine Phosphatases - genetics
Protein Tyrosine Phosphatases - metabolism
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Summary:Leptin plays a central role in weight control by suppressing food intake and increasing energy expenditure. The concept of leptin resistance emerged to explain the seemingly paradoxical elevated leptin levels in obesity. Recent discoveries reveal that protein tyrosine phosphatases are key players in leptin resistance by globally suppressing leptin signaling.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2012.02.004