Utility of FDG PET/CT in IgG4-related systemic disease

IgG4-related systemic disease (IgG4-RSD) is an emerging clinical entity about which much remains to be elucidated, in terms of its aetiology, pathogenesis, diagnosis, treatment and outcome. Autoimmune pancreatitis (AIP) and Mikulicz disease (MD) are the two major, well-studied constituents of IgG4-R...

Full description

Saved in:
Bibliographic Details
Published in:Clinical radiology 2012-04, Vol.67 (4), p.297-305
Main Authors: Nakatani, K, Nakamoto, Y, Togashi, K
Format: Article
Language:English
Subjects:
Autoimmune Diseases - diagnostic imaging
Autoimmune Diseases - drug therapy
Biological and medical sciences
Fluorodeoxyglucose F18
Humans
Immunoglobulin G
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Mikulicz' Disease - diagnostic imaging
Mikulicz' Disease - drug therapy
Multimodal Imaging
Pancreatitis - diagnostic imaging
Pancreatitis - drug therapy
Positron-Emission Tomography
Radiology
Radiopharmaceuticals
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Sialadenitis - diagnostic imaging
Sialadenitis - drug therapy
Steroids - therapeutic use
Tomography, X-Ray Computed
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:IgG4-related systemic disease (IgG4-RSD) is an emerging clinical entity about which much remains to be elucidated, in terms of its aetiology, pathogenesis, diagnosis, treatment and outcome. Autoimmune pancreatitis (AIP) and Mikulicz disease (MD) are the two major, well-studied constituents of IgG4-RSD. AIP and MD have common characteristics of forming tumour-mimicking lesions that consist of lymphoplasmacytic infiltrates and fibrosclerosis with numerous immunoglobulin G4 (IgG4)-positive plasma cells, as well as various multi-organ manifestations of IgG4-RSD. 2-[18 F]-fluoro-2-deoxy- d- glucose positron-emission tomography/ computed tomography (FDG PET/CT) enables the acquisition of whole-body images and provides functional information about disease activity; as such it has a valuable role in staging extent of disease, guiding biopsy, and monitoring response to treatment. However, FDG PET/CT is likely to be only one component of the management strategy, and clinical, laboratory, imaging and histological findings are crucial in the overall diagnosis of the condition. At present FDG PET/CT does not have a well-established role in the assessment of patients with IgG4-RSD and future prospective studies are required to define the cost-effectiveness and clinical impact in this patient group more accurately.
ISSN:0009-9260
1365-229X
DOI:10.1016/j.crad.2011.10.011