Lethal effect of dehydroleucodine (DhL) on amphibian Bufo arenarum embryos

The dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana Besser which is used in popular medicine. Toxicity tests using embryos of amphibian have been widely used in order to predict toxic effects of different compounds. However, to our knowledge, there are not studies foc...

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Bibliographic Details
Published in:Food and chemical toxicology 2012-03, Vol.50 (3-4), p.672-674
Main Authors: Moreno, Liliana Elizabeth, Juárez, Américo Osvaldo, Pelzer, Lilian Eugenia
Format: Article
Language:English
Subjects:
adverse effects
amphibians
Animals
Anuran
Artemisia douglasiana
Biological and medical sciences
Bufo
Bufo arenarum
Bufo arenarum - embryology
Dehydroleucodine
developmental stages
dose response
Dose-Response Relationship, Drug
Embryo, Nonmammalian - drug effects
Embryos
embryotoxicity
Lactones - toxicity
Medical sciences
medicine
morphogenesis
Sesquiterpenes - toxicity
Toxicity
toxicity testing
Toxicology
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Summary:The dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana Besser which is used in popular medicine. Toxicity tests using embryos of amphibian have been widely used in order to predict toxic effects of different compounds. However, to our knowledge, there are not studies focussed on the toxic effects of dehydroleucodine on Bufo arenarum, which is an anuran widely distributed in South America. The effect of dehydroleucodine on the survival of embryos was evaluated in an acute test during the early life stage of B. arenarum embryos. Lethality and the degree of adverse effects were dehydroleucodine dose-dependent. Overall, amphibian early life stages appeared to be more susceptible to the embryotoxicity associated with exposure to dehydroleucodine, especially at concentration greater that 3mM. This increased susceptibility may result from the relatively high rate of cellular differentiation and morphogenesis that occurs at this early stage of development.
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2011.12.037