Prospective study on quantitative and qualitative antimicrobial and anti-inflammatory drug use in white veal calves

Objectives To document and quantify drug use in white veal calves, an intensive livestock production system where multidrug resistance is abundantly present. Methods Drug consumption data were prospectively collected on 15 white veal production cohorts (n = 5853 calves) in Belgium (2007-09). Treatme...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2012-04, Vol.67 (4), p.1027-1038
Main Authors: Pardon, Bart, Catry, Boudewijn, Dewulf, Jeroen, Persoons, Davy, Hostens, Miel, De Bleecker, Koen, Deprez, Piet
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - therapeutic use
Anti-Inflammatory Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobial agents
Belgium
Biological and medical sciences
Cattle
Cattle Diseases - drug therapy
Drug resistance
Drug use
Drug Utilization - statistics & numerical data
Medical sciences
Pharmacology. Drug treatments
Prospective Studies
Risk factors
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Summary:Objectives To document and quantify drug use in white veal calves, an intensive livestock production system where multidrug resistance is abundantly present. Methods Drug consumption data were prospectively collected on 15 white veal production cohorts (n = 5853 calves) in Belgium (2007-09). Treatment incidences (TIs) based on animal defined daily dose (ADD), prescribed daily dose (PDD) and used daily dose (UDD) were calculated. Risk factors were identified by linear regression. Results The average TIADD of antimicrobial treatments was 416.8 ADD per 1000 animals at risk. Predominantly, oral group antimicrobial treatments were used (95.8%). Of the oral group antimicrobial treatments, 12% and 88% were used for prophylactic or metaphylactic indications, respectively. The main indication for group and individual drug use was respiratory disease. The most frequently used antimicrobials (group treatments) were oxytetracycline (23.7%), amoxicillin (18.5%), tylosin (17.2%) and colistin (15.2%). Deviations from the leaflet dosage recommendations were frequently encountered, with 43.7% of the group treatments underdosed (often oxytetracycline and tylosin to treat dysbacteriosis). In 33.3% of the oral antimicrobial group treatments a combination of two antimicrobial preparations was used. Smaller integrations used more antimicrobials in group treatments than larger ones (P 
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkr570