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Prospective study on quantitative and qualitative antimicrobial and anti-inflammatory drug use in white veal calves
Objectives To document and quantify drug use in white veal calves, an intensive livestock production system where multidrug resistance is abundantly present. Methods Drug consumption data were prospectively collected on 15 white veal production cohorts (n = 5853 calves) in Belgium (2007-09). Treatme...
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| Published in: | Journal of antimicrobial chemotherapy 2012-04, Vol.67 (4), p.1027-1038 |
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| cites | cdi_FETCH-LOGICAL-c442t-898e5b87906aa7946744ba695346f6447922f7c641640514f5642f340d69e4c03 |
| container_end_page | 1038 |
| container_issue | 4 |
| container_start_page | 1027 |
| container_title | Journal of antimicrobial chemotherapy |
| container_volume | 67 |
| creator | Pardon, Bart Catry, Boudewijn Dewulf, Jeroen Persoons, Davy Hostens, Miel De Bleecker, Koen Deprez, Piet |
| description | Objectives
To document and quantify drug use in white veal calves, an intensive livestock production system where multidrug resistance is abundantly present.
Methods
Drug consumption data were prospectively collected on 15 white veal production cohorts (n = 5853 calves) in Belgium (2007-09). Treatment incidences (TIs) based on animal defined daily dose (ADD), prescribed daily dose (PDD) and used daily dose (UDD) were calculated. Risk factors were identified by linear regression.
Results
The average TIADD of antimicrobial treatments was 416.8 ADD per 1000 animals at risk. Predominantly, oral group antimicrobial treatments were used (95.8%). Of the oral group antimicrobial treatments, 12% and 88% were used for prophylactic or metaphylactic indications, respectively. The main indication for group and individual drug use was respiratory disease. The most frequently used antimicrobials (group treatments) were oxytetracycline (23.7%), amoxicillin (18.5%), tylosin (17.2%) and colistin (15.2%). Deviations from the leaflet dosage recommendations were frequently encountered, with 43.7% of the group treatments underdosed (often oxytetracycline and tylosin to treat dysbacteriosis). In 33.3% of the oral antimicrobial group treatments a combination of two antimicrobial preparations was used. Smaller integrations used more antimicrobials in group treatments than larger ones (P |
| doi_str_mv | 10.1093/jac/dkr570 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_927988590</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/jac/dkr570</oup_id><sourcerecordid>927988590</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-898e5b87906aa7946744ba695346f6447922f7c641640514f5642f340d69e4c03</originalsourceid><addsrcrecordid>eNp90V1rFDEUBuAgSrutvekPkEGQFmHsmeQkmVyW0lahoBd6PWQzGc06H9t8rOy_N9Ndu-BFr0JOHk445yXkvIJPFSh2tdLmqv3tuYRXZFGhgJKCql6TBTDgpUTOjslJCCsAEFzUR-SYUiqoVGJBwjc_hbU10W1sEWJqt8U0Fo9Jj9FF_VTVYzsX-sM9usEZPy2d7p9e50rpxq7Xw6Dj5LdF69PPIgVbuLH488tFW2xsxkb3Gxvekjed7oM925-n5Mfd7febz-XD1_svN9cPpUGksaxVbfmylgqE1lKhkIhLLRRnKDqBKBWlnTQCK4HAK-y4QNoxhFYoiwbYKbnY9V376THZEJvBBWP7Xo92SqFReQV1zdUsL1-UFUBdI1PAM33_H11NyY95jkYxAKo4ndHHHcpbCsHbrll7N2i_zZ2aObMmZ9bsMsv43b5jWg62fab_Qsrgwx7okDfYeT0aFw6OCyaVYgc3pfVLH_4FxQ-rsQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>930029525</pqid></control><display><type>article</type><title>Prospective study on quantitative and qualitative antimicrobial and anti-inflammatory drug use in white veal calves</title><source>Oxford Journals Online</source><creator>Pardon, Bart ; Catry, Boudewijn ; Dewulf, Jeroen ; Persoons, Davy ; Hostens, Miel ; De Bleecker, Koen ; Deprez, Piet</creator><creatorcontrib>Pardon, Bart ; Catry, Boudewijn ; Dewulf, Jeroen ; Persoons, Davy ; Hostens, Miel ; De Bleecker, Koen ; Deprez, Piet</creatorcontrib><description>Objectives
To document and quantify drug use in white veal calves, an intensive livestock production system where multidrug resistance is abundantly present.
Methods
Drug consumption data were prospectively collected on 15 white veal production cohorts (n = 5853 calves) in Belgium (2007-09). Treatment incidences (TIs) based on animal defined daily dose (ADD), prescribed daily dose (PDD) and used daily dose (UDD) were calculated. Risk factors were identified by linear regression.
Results
The average TIADD of antimicrobial treatments was 416.8 ADD per 1000 animals at risk. Predominantly, oral group antimicrobial treatments were used (95.8%). Of the oral group antimicrobial treatments, 12% and 88% were used for prophylactic or metaphylactic indications, respectively. The main indication for group and individual drug use was respiratory disease. The most frequently used antimicrobials (group treatments) were oxytetracycline (23.7%), amoxicillin (18.5%), tylosin (17.2%) and colistin (15.2%). Deviations from the leaflet dosage recommendations were frequently encountered, with 43.7% of the group treatments underdosed (often oxytetracycline and tylosin to treat dysbacteriosis). In 33.3% of the oral antimicrobial group treatments a combination of two antimicrobial preparations was used. Smaller integrations used more antimicrobials in group treatments than larger ones (P < 0.05); an integration is defined as a company that combines all steps of the production chain by having its own feed plant and slaughterhouse and by placing its calves in veal herds owned by producers that fatten these calves for this integration on contract. Producers used higher dosages than prescribed by the veterinarian in cohorts with a single caretaker (P < 0.01).
Conclusions
The present study provided detailed information on the intensive antimicrobial use in the white veal industry. Reduction can only be achieved by reducing the number of oral group treatments.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/dkr570</identifier><identifier>PMID: 22262796</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Anti-Bacterial Agents - therapeutic use ; Anti-Inflammatory Agents - therapeutic use ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antimicrobial agents ; Belgium ; Biological and medical sciences ; Cattle ; Cattle Diseases - drug therapy ; Drug resistance ; Drug use ; Drug Utilization - statistics & numerical data ; Medical sciences ; Pharmacology. Drug treatments ; Prospective Studies ; Risk factors</subject><ispartof>Journal of antimicrobial chemotherapy, 2012-04, Vol.67 (4), p.1027-1038</ispartof><rights>The Author 2012. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com 2012</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Apr 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-898e5b87906aa7946744ba695346f6447922f7c641640514f5642f340d69e4c03</citedby><cites>FETCH-LOGICAL-c442t-898e5b87906aa7946744ba695346f6447922f7c641640514f5642f340d69e4c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25637993$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22262796$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pardon, Bart</creatorcontrib><creatorcontrib>Catry, Boudewijn</creatorcontrib><creatorcontrib>Dewulf, Jeroen</creatorcontrib><creatorcontrib>Persoons, Davy</creatorcontrib><creatorcontrib>Hostens, Miel</creatorcontrib><creatorcontrib>De Bleecker, Koen</creatorcontrib><creatorcontrib>Deprez, Piet</creatorcontrib><title>Prospective study on quantitative and qualitative antimicrobial and anti-inflammatory drug use in white veal calves</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>Objectives
To document and quantify drug use in white veal calves, an intensive livestock production system where multidrug resistance is abundantly present.
Methods
Drug consumption data were prospectively collected on 15 white veal production cohorts (n = 5853 calves) in Belgium (2007-09). Treatment incidences (TIs) based on animal defined daily dose (ADD), prescribed daily dose (PDD) and used daily dose (UDD) were calculated. Risk factors were identified by linear regression.
Results
The average TIADD of antimicrobial treatments was 416.8 ADD per 1000 animals at risk. Predominantly, oral group antimicrobial treatments were used (95.8%). Of the oral group antimicrobial treatments, 12% and 88% were used for prophylactic or metaphylactic indications, respectively. The main indication for group and individual drug use was respiratory disease. The most frequently used antimicrobials (group treatments) were oxytetracycline (23.7%), amoxicillin (18.5%), tylosin (17.2%) and colistin (15.2%). Deviations from the leaflet dosage recommendations were frequently encountered, with 43.7% of the group treatments underdosed (often oxytetracycline and tylosin to treat dysbacteriosis). In 33.3% of the oral antimicrobial group treatments a combination of two antimicrobial preparations was used. Smaller integrations used more antimicrobials in group treatments than larger ones (P < 0.05); an integration is defined as a company that combines all steps of the production chain by having its own feed plant and slaughterhouse and by placing its calves in veal herds owned by producers that fatten these calves for this integration on contract. Producers used higher dosages than prescribed by the veterinarian in cohorts with a single caretaker (P < 0.01).
Conclusions
The present study provided detailed information on the intensive antimicrobial use in the white veal industry. Reduction can only be achieved by reducing the number of oral group treatments.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antimicrobial agents</subject><subject>Belgium</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Cattle Diseases - drug therapy</subject><subject>Drug resistance</subject><subject>Drug use</subject><subject>Drug Utilization - statistics & numerical data</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Risk factors</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp90V1rFDEUBuAgSrutvekPkEGQFmHsmeQkmVyW0lahoBd6PWQzGc06H9t8rOy_N9Ndu-BFr0JOHk445yXkvIJPFSh2tdLmqv3tuYRXZFGhgJKCql6TBTDgpUTOjslJCCsAEFzUR-SYUiqoVGJBwjc_hbU10W1sEWJqt8U0Fo9Jj9FF_VTVYzsX-sM9usEZPy2d7p9e50rpxq7Xw6Dj5LdF69PPIgVbuLH488tFW2xsxkb3Gxvekjed7oM925-n5Mfd7febz-XD1_svN9cPpUGksaxVbfmylgqE1lKhkIhLLRRnKDqBKBWlnTQCK4HAK-y4QNoxhFYoiwbYKbnY9V376THZEJvBBWP7Xo92SqFReQV1zdUsL1-UFUBdI1PAM33_H11NyY95jkYxAKo4ndHHHcpbCsHbrll7N2i_zZ2aObMmZ9bsMsv43b5jWg62fab_Qsrgwx7okDfYeT0aFw6OCyaVYgc3pfVLH_4FxQ-rsQ</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Pardon, Bart</creator><creator>Catry, Boudewijn</creator><creator>Dewulf, Jeroen</creator><creator>Persoons, Davy</creator><creator>Hostens, Miel</creator><creator>De Bleecker, Koen</creator><creator>Deprez, Piet</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20120401</creationdate><title>Prospective study on quantitative and qualitative antimicrobial and anti-inflammatory drug use in white veal calves</title><author>Pardon, Bart ; Catry, Boudewijn ; Dewulf, Jeroen ; Persoons, Davy ; Hostens, Miel ; De Bleecker, Koen ; Deprez, Piet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-898e5b87906aa7946744ba695346f6447922f7c641640514f5642f340d69e4c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antimicrobial agents</topic><topic>Belgium</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Cattle Diseases - drug therapy</topic><topic>Drug resistance</topic><topic>Drug use</topic><topic>Drug Utilization - statistics & numerical data</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pardon, Bart</creatorcontrib><creatorcontrib>Catry, Boudewijn</creatorcontrib><creatorcontrib>Dewulf, Jeroen</creatorcontrib><creatorcontrib>Persoons, Davy</creatorcontrib><creatorcontrib>Hostens, Miel</creatorcontrib><creatorcontrib>De Bleecker, Koen</creatorcontrib><creatorcontrib>Deprez, Piet</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pardon, Bart</au><au>Catry, Boudewijn</au><au>Dewulf, Jeroen</au><au>Persoons, Davy</au><au>Hostens, Miel</au><au>De Bleecker, Koen</au><au>Deprez, Piet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective study on quantitative and qualitative antimicrobial and anti-inflammatory drug use in white veal calves</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>67</volume><issue>4</issue><spage>1027</spage><epage>1038</epage><pages>1027-1038</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>Objectives
To document and quantify drug use in white veal calves, an intensive livestock production system where multidrug resistance is abundantly present.
Methods
Drug consumption data were prospectively collected on 15 white veal production cohorts (n = 5853 calves) in Belgium (2007-09). Treatment incidences (TIs) based on animal defined daily dose (ADD), prescribed daily dose (PDD) and used daily dose (UDD) were calculated. Risk factors were identified by linear regression.
Results
The average TIADD of antimicrobial treatments was 416.8 ADD per 1000 animals at risk. Predominantly, oral group antimicrobial treatments were used (95.8%). Of the oral group antimicrobial treatments, 12% and 88% were used for prophylactic or metaphylactic indications, respectively. The main indication for group and individual drug use was respiratory disease. The most frequently used antimicrobials (group treatments) were oxytetracycline (23.7%), amoxicillin (18.5%), tylosin (17.2%) and colistin (15.2%). Deviations from the leaflet dosage recommendations were frequently encountered, with 43.7% of the group treatments underdosed (often oxytetracycline and tylosin to treat dysbacteriosis). In 33.3% of the oral antimicrobial group treatments a combination of two antimicrobial preparations was used. Smaller integrations used more antimicrobials in group treatments than larger ones (P < 0.05); an integration is defined as a company that combines all steps of the production chain by having its own feed plant and slaughterhouse and by placing its calves in veal herds owned by producers that fatten these calves for this integration on contract. Producers used higher dosages than prescribed by the veterinarian in cohorts with a single caretaker (P < 0.01).
Conclusions
The present study provided detailed information on the intensive antimicrobial use in the white veal industry. Reduction can only be achieved by reducing the number of oral group treatments.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>22262796</pmid><doi>10.1093/jac/dkr570</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of antimicrobial chemotherapy, 2012-04, Vol.67 (4), p.1027-1038 |
| issn | 0305-7453 1460-2091 |
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| source | Oxford Journals Online |
| subjects | Animals Anti-Bacterial Agents - therapeutic use Anti-Inflammatory Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial agents Belgium Biological and medical sciences Cattle Cattle Diseases - drug therapy Drug resistance Drug use Drug Utilization - statistics & numerical data Medical sciences Pharmacology. Drug treatments Prospective Studies Risk factors |
| title | Prospective study on quantitative and qualitative antimicrobial and anti-inflammatory drug use in white veal calves |
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