PGC1α gene Gly482Ser polymorphism predicts improved metabolic, inflammatory and vascular outcomes following bariatric surgery

• Published in: International Journal of Obesity 2012-03, Vol.36 (3), p.363-368
• Main Authors: Geloneze, S R, Geloneze, B, Morari, J, Matos-Souza, J R, Lima, M M, Chaim, E A, Pareja, J C, Velloso, L A
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Biological and medical sciences; Brazil - epidemiology; C-Reactive Protein - genetics; Care and treatment; Carotid Intima-Media Thickness; Comorbidity; Coronary Artery Disease - epidemiology; Coronary Artery Disease - genetics; Coronary Artery Disease - pathology; Coronary Artery Disease - prevention & control; Diagnosis; Epidemiology; Female; Gastric Bypass - methods; Genetic aspects; Genetic polymorphisms; Glycine; Health aspects; Health Promotion and Disease Prevention; Humans; Inflammation; Interleukin-6 - genetics; Internal Medicine; Male; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Middle Aged; Obesity; Obesity, Morbid - epidemiology; Obesity, Morbid - genetics; Obesity, Morbid - surgery; original-article; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Public Health; Serine; Stomach, duodenum, intestine, rectum, anus; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Treatment Outcome; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels; Weight Loss; Young Adult
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/ijo.2011.176

Aims/Hypothesis: Bariatric surgery is currently employed as an effective approach to treat class III obesity and class II obesity with co-morbidities. Unfortunately, the general anthropometric and metabolic outcomes of the surgery are not homogeneous, and defining the eligibility criteria that allow for a more precise prediction of the outcomes of this invasive procedure will refine the selection of patients. Here we tested the hypothesis that the Gly482Ser polymorphism of the ppargc1a gene would predict different outcomes following bariatric surgery. Methods: Fifty-five patients (26 Gly/Gly and 29 Gly/Ser+Ser/Ser) selected for the Roux-en-Y gastric bypass according to the National Institutes of Health Consensus Statement criteria were followed up for 1 year, monitoring their anthropometric, metabolic and inflammatory parameters. Results: Patients with the Gly482Ser polymorphism had significantly improved reductions in the waist/hip ratio, fasting blood glucose, C-reactive protein, blood leukocyte count, serum interleukin-6 and intima–media thickness of the carotid artery, as compared with Gly/Gly patients. Conclusions/Interpretation: Thus, the Gly482Ser polymorphism may predict a more favorable metabolic and inflammatory outcome for obese patients submitted to bariatric surgery, leading to a reduced atherosclerotic risk.