Loading…
Sterols from a soft coral, Dendronephthya gigantea as farnesoid X-activated receptor antagonists
► Three new steroids 1–3 were isolated from a marine organism Dendronephthya gigantea. ► Relative stereochemistry was elucidated by the analysis of HRMS and 2-D NMR. ► New steroids 1 and 2 showed potent inhibitory activity against FXR. Three new steroids 3-oxocholest-1,22-dien-12β-ol (1), 3-oxochole...
Saved in:
Published in: | Steroids 2012-04, Vol.77 (5), p.355-359 |
---|---|
Main Authors: | , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | ► Three new steroids 1–3 were isolated from a marine organism Dendronephthya gigantea. ► Relative stereochemistry was elucidated by the analysis of HRMS and 2-D NMR. ► New steroids 1 and 2 showed potent inhibitory activity against FXR.
Three new steroids 3-oxocholest-1,22-dien-12β-ol (1), 3-oxocholest-1,4-dien-20β-ol (2), 3-oxocholest-1,4-dien-12β-ol (3), and three known steroids (20S)-20-Hydroxyergosta-1,4,24(28)-trien-3-one (4) [7a], 5α,8α-Epidioxycholesta-6,22-dien-3β-ol (5) [10] and 5-cholestene-3β,12β-diol (6) [11] were isolated from a soft coral Dendronephthya gigantea. Their chemical structures and relative stereochemistry were elucidated by the analysis of HRMS and 2-D NMR spectroscopic data. The steroids 1 and 2 showed notable inhibitory activity against farnesoid X-activated receptor (FXR) with IC50’s 14 and 15μM. |
---|---|
ISSN: | 0039-128X 1878-5867 |
DOI: | 10.1016/j.steroids.2011.12.027 |