Carbon-Centered Radicals Can Transfer Hydrogen Atoms between Amino Acid Side Chains

Radical migration between aliphatic amino acid side chains can occur in solution and intramolecularly in peptides. The kinetic constant of the hydrogen transfer reaction was measured by using competition kinetics, and the half‐life as well as the distance that a radical can move within a protein was...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-03, Vol.51 (12), p.2960-2963
Main Authors: Raffy, Quentin, Buisson, David-Alexandre, Cintrat, Jean-Christophe, Rousseau, Bernard, Pin, Serge, Renault, Jean Philippe
Format: Article
Language:English
Subjects:
amino acids
Amino Acids - chemistry
Carbon - chemistry
Deuterium - chemistry
Deuterium Exchange Measurement
Free Radicals - chemistry
Half-Life
Hydrogen - chemistry
hydrogen transfer
Kinetics
proteins
Proteins - chemistry
radical reactions
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Summary:Radical migration between aliphatic amino acid side chains can occur in solution and intramolecularly in peptides. The kinetic constant of the hydrogen transfer reaction was measured by using competition kinetics, and the half‐life as well as the distance that a radical can move within a protein was calculated.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201108856