Pathogen detection using engineered bacteriophages

Bacteriophages, or phages, are bacterial viruses that can infect a broad or narrow range of host organisms. Knowing the host range of a phage allows it to be exploited in targeting various pathogens. Applying phages for the identification of microorganisms related to food and waterborne pathogens an...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2012-04, Vol.402 (10), p.3127-3146
Main Authors: Smartt, Abby E., Xu, Tingting, Jegier, Patricia, Carswell, Jessica J., Blount, Samuel A., Sayler, Gary S., Ripp, Steven
Format: Article
Language:English
Subjects:
Analytical Chemistry
Animals
Bacteria
Bacteria - classification
Bacteria - isolation & purification
Bacteria - pathogenicity
Bacteria - virology
Bacterial Infections - microbiology
Bacteriophages
Bacteriophages - chemistry
Bacteriophages - genetics
Bacteriophages - physiology
Biochemistry
Biosensing Techniques - instrumentation
Biosensing Techniques - methods
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Detection equipment
Detectors
Food Microbiology
Food Science
Genetic Engineering
Genetically modified organisms
Humans
Laboratory Medicine
Monitoring/Environmental Analysis
Pathogens
Phage
Readers
Review
Strategy
Viruses
Water Microbiology
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Description
Summary:Bacteriophages, or phages, are bacterial viruses that can infect a broad or narrow range of host organisms. Knowing the host range of a phage allows it to be exploited in targeting various pathogens. Applying phages for the identification of microorganisms related to food and waterborne pathogens and pathogens of clinical significance to humans and animals has a long history, and there has to some extent been a recent revival in these applications as phages have become more extensively integrated into novel detection, identification, and monitoring technologies. Biotechnological and genetic engineering strategies applied to phages are responsible for some of these new methods, but even natural unmodified phages are widely applicable when paired with appropriate innovative detector platforms. This review highlights the use of phages as pathogen detector interfaces to provide the reader with an up-to-date inventory of phage-based biodetection strategies.
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-011-5555-5