Stimulation of the endometrium with high-grade blastocyst culture supernatant (SEHB) can improve pregnancy outcome for couples undergoing intracytoplasmic sperm injection (ICSI): a randomized clinical trial

Purpose To evaluate the impact of stimulating the endometrium with high-grade blastocyst culture supernatant (SEHB) perfusion before blastocyst transfer (BT) on implantation rate, pregnancy rate, and pregnancy outcome in ICSI cycles. Materials and methods Ninety-four infertile couples who were refer...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2012-04, Vol.285 (4), p.1167-1171
Main Authors: Tehraninejad, Ensieh Shahrokhe, Tanha, Fateme Davari, Ghajarzadeh, Mahsa, Zandieh, Zahra, Aziminekoo, Elham, Zanjani, Haleh Rahmanpour
Format: Article
Language:English
Subjects:
Abortion
Adult
Clinical trials
Embryo Implantation
Embryo Transfer - methods
Endocrinology
Endometrium - physiology
Female
Fertility
Gynecology
Human Genetics
Humans
Infertility - therapy
Male
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Ovulation Induction
Pregnancy
Pregnancy Outcome
Pregnancy Rate
Reproductive Medicine
Sperm Injections, Intracytoplasmic
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Summary:Purpose To evaluate the impact of stimulating the endometrium with high-grade blastocyst culture supernatant (SEHB) perfusion before blastocyst transfer (BT) on implantation rate, pregnancy rate, and pregnancy outcome in ICSI cycles. Materials and methods Ninety-four infertile couples who were referred to the Valiasr department of Imam Hospital complex between January 2010 and March 2011 enrolled in this randomized clinical trial. They were randomly divided into only BT or SEHB groups. Implantation rates, pregnancy rates, abortion, preterm and term delivery rates were compared between the two groups. Results Implantation rates and pregnancy rates did not differ significantly between the two groups. The abortion rate was significantly higher in the BT only group while term delivery was significantly higher in SEHB group. Odds ratios of term delivery and abortion were 4.5 ( p  = 0.001) and 0.3 ( p  = 0.04), respectively. Conclusion The SEHB application may improve pregnancy outcome in infertile couples who are candidates for the ICSI reproductive method.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-011-2143-z