Hypoglycemic Activity of Gymnema sylvestre Extracts on Oxidative Stress and Antioxidant Status in Diabetic Rats

Diabetes mellitus, which is associated with oxidative damage, has a significant impact on health, quality of life, and life expectancy. An ethanol extract of Gymnema sylvestre leaf was examined in vitro and in vivo to investigate the role of antioxidants in diabetic rats. The extract exhibited stron...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2012-03, Vol.60 (10), p.2517-2524
Main Authors: Kang, Myung-Hwa, Lee, Min Sun, Choi, Mi-Kyeong, Min, Kwan-Sik, Shibamoto, Takayuki
Format: Article
Language:English
Subjects:
acids
alanine transaminase
Animals
antioxidant activity
Antioxidants - metabolism
Biological and medical sciences
blood glucose
Blood Glucose - analysis
diabetes mellitus
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - metabolism
ethanol
Food industries
Fundamental and applied biological sciences. Psychology
glutathione peroxidase
glycemic effect
Gymnema sylvestre
Gymnema sylvestre - chemistry
Humans
Hypoglycemic Agents - administration & dosage
kidneys
leaves
Lipid Peroxidation
liver
longevity
Male
oxidative stress
Oxidative Stress - drug effects
Plant Extracts - administration & dosage
Plant Leaves - chemistry
quality of life
Rats
Rats, Sprague-Dawley
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Summary:Diabetes mellitus, which is associated with oxidative damage, has a significant impact on health, quality of life, and life expectancy. An ethanol extract of Gymnema sylvestre leaf was examined in vitro and in vivo to investigate the role of antioxidants in diabetic rats. The extract exhibited strong antioxidant activity in the assays, including TBA (56%), SOD-like (92%), and ABTS (54%). Blood glucose levels in the diabetic rats fed G. sylvestre extract decreased to normal levels. The presence of the antihyperglycemic compounds gymnemagenin and gymnemic acids in G. sylvestre extract was detected by LC/MS analysis. Lipid peroxidation levels were decreased by 31.7% in serum, 9.9% in liver, and 9.1% in kidney in the diabetic rats fed the extract. Feeding G. sylvestre extract to the diabetic rats decreased the activity of glutathione peroxidase in cytosolic liver and glutamate pyruvate transaminase in serum to normal levels.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf205086b