Titanium-nitride-oxIde-coated stents multicenter registry in diaBEtic patienTs: the TIBET registry

• Published in: Heart and vessels 2012-03, Vol.27 (2), p.151-158
• Main Authors: Chavarri, Mariano Valdés, Bethencourt, Armando, Pinar, Eduardo, Gomez, Alfredo, Portales, Javier Fernández, Pomar, Francisco, Calvo, Isabel, Minguez, Jose Ramón López, Valdesuso, Raúl, Moreu, José, Martínez, Antonio, Nammas, Wail
• Format: Article
• Language: English
• Subjects: Aged; Angioplasty, Balloon, Coronary - adverse effects; Angioplasty, Balloon, Coronary - instrumentation; Angioplasty, Balloon, Coronary - mortality; Biomedical Engineering and Bioengineering; Cardiac Surgery; Cardiology; Cardiovascular disease; Clinical outcomes; Coated Materials, Biocompatible; Coronary Angiography; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - mortality; Coronary Artery Disease - therapy; Diabetes; Diabetic Angiopathies - diagnostic imaging; Diabetic Angiopathies - mortality; Diabetic Angiopathies - therapy; Female; Humans; Male; Medical imaging; Medicine; Medicine & Public Health; Middle Aged; Myocardial Infarction - mortality; Myocardial Infarction - prevention & control; Original Article; Prospective Studies; Prosthesis Design; Registries; Spain - epidemiology; Stents; Thrombosis - mortality; Time Factors; Titanium; Treatment Outcome; Vascular Surgery
• ISSN: 0910-8327; 1615-2573
• DOI: 10.1007/s00380-011-0136-2

We sought to explore the immediate clinical and angiographic results of the Titan ® stent implantation in diabetic patients, as well as the major adverse cardiac events (MACE) at 6-month follow-up. We enrolled 156 consecutive diabetic patients admitted to undergo percutaneous intervention for at least one significant (50%) coronary lesion. All lesions were treated with the Titan ® stent implantation according to the contemporary interventional techniques. Patients were prospectively followed-up for at least 6 months. The primary endpoint was MACE at 6-month follow-up [cardiac death, myocardial infarction (MI), or target lesion revascularization (TLR)]. Secondary endpoints included angiographic and clinical procedural success, in-hospital MACE, TLR at 6-month follow-up, and stent thrombosis. The mean age was 66.7 ± 9.6 years, (68.4% males). A total of 197 Titan ® stents were implanted in 163 lesions. Direct stenting was performed in 45.2% of the cases. The mean stent diameter was 3.1 ± 0.61 mm, and the mean length was 18.0 ± 8.9 mm. Average stent deployment pressure was 13.9 ± 4.2 bars. Angiographic procedural success was achieved in 154 (98.7%) cases, and clinical procedural success was achieved in 153 (98.1%) cases. One patient developed in-hospital non-Q-wave MI following the procedure. Clinical follow-up was completed in 155 (99.4%) patients. Three patients (1.9%) died of a cardiac or unknown cause, and two (1.3%) developed MI. TLR was performed in 11 patients (7.1%). Cumulative MACE at 6-month follow-up occurred in 16 (10.3%) patients. No patient suffered stent thrombosis. Titan ® stent implantation in diabetic patients achieves an excellent immediate clinical and angiographic outcome, with a low incidence of MACE at mid-term follow-up.