Elevated γ-glutamyltransferase in implantable cardioverter defibrillator patients

Summary BACKGROUND: Elevated γ-glutamyltransferase (GGT) is a new risk factor for cardiovascular diseases, but its impact on ventricular tachyarrhythmia occurrence and survival in patients with an implantable cardioverter defibrillator (ICD) is unknown. METHODS AND RESULTS: Considering that GGT leve...

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Published in:Wiener Klinische Wochenschrift 2012, Vol.124 (1-2), p.18-24
Main Authors: Dichtl, Wolfgang, Wolber, Thomas, Paoli, Ursula, Theurl, Thomas, Brüllmann, Simon, Stühlinger, Markus, Berger, Thomas, Spuller, Karin, Strasak, Alexander, Pachinger, Otmar, Haegeli, Laurent, Duru, Firat, Hintringer, Florian
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Austria - epidemiology
Biomarkers - blood
Comorbidity
Defibrillators, Implantable - statistics & numerical data
Electric Countershock - mortality
Endocrinology
Female
gamma-Glutamyltransferase - blood
Gastroenterology
Heart Failure - blood
Heart Failure - mortality
Heart Failure - prevention & control
Humans
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Pneumology/Respiratory System
Prevalence
Risk Assessment - methods
Risk Factors
Survival Analysis
Survival Rate
Switzerland - epidemiology
Ventricular Fibrillation - blood
Ventricular Fibrillation - mortality
Ventricular Fibrillation - prevention & control
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Summary:Summary BACKGROUND: Elevated γ-glutamyltransferase (GGT) is a new risk factor for cardiovascular diseases, but its impact on ventricular tachyarrhythmia occurrence and survival in patients with an implantable cardioverter defibrillator (ICD) is unknown. METHODS AND RESULTS: Considering that GGT levels are gender-dependent, female ICD recipients were excluded from our database because of the low incidence of events. In a retrospective analysis, appropriate ICD therapy (both shocks and antitachycardia pacing due to ventricular tachyarrhythmias) occurred in 31.9% of 320 male patients who had received an ICD for primary prevention (median follow-up of 2.3 years), and in 55.1% of 423 male patients who had received an ICD for secondary prevention (median follow-up of 3.9 years). Compared to normal low GGT plasma levels (below 28 U/L), total mortality but not risk for appropriate ICD therapy was elevated for higher GGT categories ( p for trend = 0.004 in primary prevention and p for trend = 0.002 in secondary prevention, respectively). In Cox regression analysis, elevated GGT (>56 U/L) remained an independent predictor of death both in primary ( p = 0.011) and in secondary prevention ( p = 0.006). Patients with elevated GGT and renal insufficiency defined by an estimated glomerular filtration rate
ISSN:0043-5325
1613-7671
DOI:10.1007/s00508-011-0046-4