A multi-centre pathologist survey on pathological processing and regression grading of colorectal cancer resection specimens treated by neoadjuvant chemoradiation

To ascertain the approach and degree of consensus of pathologists in the handling and regression grading of colorectal cancer resection specimens treated with neoadjuvant chemoradiation, a ten-part questionnaire was circulated to 18 gastrointestinal pathologists in eight countries. The questions wer...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2012-02, Vol.460 (2), p.151-155
Main Authors: Chetty, Runjan, Gill, Pelvender, Govender, Dhirendra, Bateman, Adrian, Chang, Hee Jin, Driman, David, Duthie, Fraser, Gomez, Marisa, Jaynes, Eleanor, Lee, Cheok Soon, Locketz, Michael, Mescoli, Claudia, Rowsell, Corwyn, Rullier, Anne, Serra, Stefano, Shepherd, Neil, Szentgyorgyi, Eva, Vajpeyi, Rajkumar, Wang, Lai Mun
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Adenocarcinoma - therapy
Biological and medical sciences
Chemoradiotherapy
Colorectal carcinoma
Colorectal Neoplasms - pathology
Colorectal Neoplasms - therapy
Data Collection
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Medicine
Medicine & Public Health
Neoadjuvant Therapy
Neoplasm Grading - methods
Neoplasm Grading - standards
Original Article
Pathology
Pathology, Surgical - standards
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Specimen Handling - methods
Specimen Handling - standards
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:To ascertain the approach and degree of consensus of pathologists in the handling and regression grading of colorectal cancer resection specimens treated with neoadjuvant chemoradiation, a ten-part questionnaire was circulated to 18 gastrointestinal pathologists in eight countries. The questions were specific and addressed pertinent issues related to colorectal cancer with neoadjuvant chemoradiation. There is a lack of consensus on how to handle the specimen, number of sections taken, correlation with pre- and post-operative radiological imaging, and especially, regression grading schema employed. Consensus in the form of guidelines is required so that the pathological assessment of these specimens will provide clinically relevant information for patient management, irrespective of location.
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-012-1193-3