Effect of normobaric hyperoxia on the markers of bone tissue metabolism

We studied the influencing of normobaric hyperoxia one hour daily during 14 and 28 days on the bone metabolism for 3- and 12-monthly Wistar male-rats (n =80). It was shown, that breathed normobaric gas mixture with 90% O2 during 14 days significant reducing of C-terminal propeptides of type I collag...

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Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2011, Vol.57 (6), p.65-70
Main Authors: Berezovs'kyĭ, V Ia, Zamors'ka, T M, Litovka, I H, Ianko, R V
Format: Article
Language:Ukrainian
Subjects:
Aging - blood
Aging - metabolism
Amino Acids - blood
Amino Acids - metabolism
Animals
Biomarkers - blood
Biomarkers - metabolism
Bone and Bones - metabolism
Bone Development - physiology
Hyperoxia - blood
Hyperoxia - metabolism
Hyperoxia - physiopathology
Male
Peptide Fragments - blood
Peptide Fragments - metabolism
Procollagen - blood
Procollagen - metabolism
Rats
Rats, Wistar
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Summary:We studied the influencing of normobaric hyperoxia one hour daily during 14 and 28 days on the bone metabolism for 3- and 12-monthly Wistar male-rats (n =80). It was shown, that breathed normobaric gas mixture with 90% O2 during 14 days significant reducing of C-terminal propeptides of type I collagen levels for 36%, an increasing piridinolin levels for 37% and concentration of C-terminal telopeptides of type I collagen for 8% in the blood serum. We found reliable decreasing the concentration ofpiridinolin levels for 27% in adult rats in the same conditions. The C-terminal propeptides of type I collagen levels did not change in any of the groups' research. We believe that 14 days normobaric hyperoxia (90%) in young animals accompanied by violation of collagen synthesis. The adult rats were more stable and had no changes after influence the two hyperoxia levels.
ISSN:2522-9028