Effect of normobaric hyperoxia on the markers of bone tissue metabolism

• Published in: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2011, Vol.57 (6), p.65-70
• Main Authors: Berezovs'kyĭ, V Ia, Zamors'ka, T M, Litovka, I H, Ianko, R V
• Format: Article
• Language: Ukrainian
• Subjects: Aging - blood; Aging - metabolism; Amino Acids - blood; Amino Acids - metabolism; Animals; Biomarkers - blood; Biomarkers - metabolism; Bone and Bones - metabolism; Bone Development - physiology; Hyperoxia - blood; Hyperoxia - metabolism; Hyperoxia - physiopathology; Male; Peptide Fragments - blood; Peptide Fragments - metabolism; Procollagen - blood; Procollagen - metabolism; Rats; Rats, Wistar
• ISSN: 2522-9028

We studied the influencing of normobaric hyperoxia one hour daily during 14 and 28 days on the bone metabolism for 3- and 12-monthly Wistar male-rats (n =80). It was shown, that breathed normobaric gas mixture with 90% O2 during 14 days significant reducing of C-terminal propeptides of type I collagen levels for 36%, an increasing piridinolin levels for 37% and concentration of C-terminal telopeptides of type I collagen for 8% in the blood serum. We found reliable decreasing the concentration ofpiridinolin levels for 27% in adult rats in the same conditions. The C-terminal propeptides of type I collagen levels did not change in any of the groups' research. We believe that 14 days normobaric hyperoxia (90%) in young animals accompanied by violation of collagen synthesis. The adult rats were more stable and had no changes after influence the two hyperoxia levels.