Comment on "Widespread RNA and DNA sequence differences in the human transcriptome"

Li et al. (Research Articles, 1 July 2011, p. 53; published online 19 May 2011) reported large numbers of differences between DNA and messenger RNA in human cells, indicating unprecedented levels of RNA editing, and including sequence changes not produced by any of the known RNA editing mechanisms....

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2012-03, Vol.335 (6074), p.1302; author reply 1302-1302
Main Authors: Kleinman, Claudia L, Majewski, Jacek
Format: Article
Language:English
Subjects:
Deoxyribonucleic acid
DNA
DNA - genetics
Genetic Variation
Genetics
Genome, Human
Genotype & phenotype
Humans
Indexing in process
Ribonucleic acid
RNA
RNA, Messenger - genetics
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Summary:Li et al. (Research Articles, 1 July 2011, p. 53; published online 19 May 2011) reported large numbers of differences between DNA and messenger RNA in human cells, indicating unprecedented levels of RNA editing, and including sequence changes not produced by any of the known RNA editing mechanisms. However, common sources of systematic errors in high-throughput sequencing technology, which were not properly accounted for in this study, explain most of the claimed differences.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1209658