Regeneration of skeletal muscle

Skeletal muscle has a robust capacity for regeneration following injury. However, few if any effective therapeutic options for volumetric muscle loss are available. Autologous muscle grafts or muscle transposition represent possible salvage procedures for the restoration of mass and function but the...

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Bibliographic Details
Published in:Cell and tissue research 2012-03, Vol.347 (3), p.759-774
Main Authors: Turner, Neill J., Badylak, Stephen F.
Format: Article
Language:English
Subjects:
Animals
Biomechanical Phenomena - physiology
Biomedical and Life Sciences
Biomedicine
Genetic disorders
Health aspects
Human Genetics
Humans
Inflammatory diseases
Molecular Medicine
Muscle, Skeletal - blood supply
Muscle, Skeletal - immunology
Muscle, Skeletal - innervation
Muscle, Skeletal - physiology
Muscles
Muscular system
Neovascularization, Physiologic
Proteomics
Regeneration - physiology
Review
Skeletal system
Stem cells
Stem Cells - cytology
Wound Healing
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Summary:Skeletal muscle has a robust capacity for regeneration following injury. However, few if any effective therapeutic options for volumetric muscle loss are available. Autologous muscle grafts or muscle transposition represent possible salvage procedures for the restoration of mass and function but these approaches have limited success and are plagued by associated donor site morbidity. Cell-based therapies are in their infancy and, to date, have largely focused on hereditary disorders such as Duchenne muscular dystrophy. An unequivocal need exists for regenerative medicine strategies that can enhance or induce de novo formation of functional skeletal muscle as a treatment for congenital absence or traumatic loss of tissue. In this review, the three stages of skeletal muscle regeneration and the potential pitfalls in the development of regenerative medicine strategies for the restoration of functional skeletal muscle in situ are discussed.
ISSN:0302-766X
1432-0878
DOI:10.1007/s00441-011-1185-7