Ulnar artery occlusion is predictive of digital ulcers in SSc: a duplex sonography study

To assess the prevalence and risk factors of ulnar artery occlusion (UAO) in an unselected SSc patient cohort and to determine whether UAO is associated with digital ulcers (DUs). A total of 79 SSc patients and 40 'healthy' controls underwent colour duplex sonography of the radial and ulna...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2012-04, Vol.51 (4), p.735-742
Main Authors: FRERIX, Marc, STEGBAUER, Johannes, DRAGUN, Duska, KREUTER, Alexander, WEINER, Stefan M
Format: Article
Language:English
Subjects:
Aged
Arterial Occlusive Diseases - diagnostic imaging
Arterial Occlusive Diseases - etiology
Arterial Occlusive Diseases - immunology
Autoantibodies - blood
Biological and medical sciences
Blood and lymphatic vessels
Blood Flow Velocity - physiology
Cardiology. Vascular system
Case-Control Studies
Diseases of the osteoarticular system
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Fingers
Hand Dermatoses - diagnostic imaging
Hand Dermatoses - etiology
Hand Dermatoses - physiopathology
Humans
Male
Medical sciences
Middle Aged
Radial Artery - diagnostic imaging
Radial Artery - physiopathology
Receptor, Angiotensin, Type 1 - immunology
Receptor, Endothelin A - immunology
Regional Blood Flow - physiology
Risk Factors
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Scleroderma, Systemic - complications
Scleroderma, Systemic - diagnostic imaging
Skin Ulcer - diagnostic imaging
Skin Ulcer - etiology
Skin Ulcer - physiopathology
Ulnar Artery - diagnostic imaging
Ulnar Artery - physiopathology
Ultrasonography, Doppler, Color - methods
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Summary:To assess the prevalence and risk factors of ulnar artery occlusion (UAO) in an unselected SSc patient cohort and to determine whether UAO is associated with digital ulcers (DUs). A total of 79 SSc patients and 40 'healthy' controls underwent colour duplex sonography of the radial and ulnar artery to compare blood flow velocity, resistive indices (RIs) and presence of occlusion and were followed for a mean of 53 months. In both, radial and ulnar arteries, peak systolic velocity (PSV) and end-diastolic velocity (EDV) were significantly lower and RI higher in SSc patients compared with controls (PSVrad: 40.1 vs 48.6 cm/s; PSVuln 38.2 vs 56.6 cm/s; EDVrad 3.8 vs 10.4 cm/s; EDVuln 3.0 vs 13.0 cm/s; RIrad 0.91 vs 0.82; RIuln 0.92 vs 0.80; all P 
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/ker414