Association Between Red Cell Distribution Width and Disease Activity in Patients with Inflammatory Bowel Disease

Background Recent studies have suggested that a higher red blood cell distribution width (RDW) is associated with disease activity in patients with inflammatory bowel disease (IBD). However, the RDW in IBD patients without anemia has not been investigated. Aim This study aimed to determine whether o...

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Bibliographic Details
Published in:Digestive diseases and sciences 2012-04, Vol.57 (4), p.1033-1038
Main Authors: Song, Chang Seok, Park, Dong Il, Yoon, Min Yong, Seok, Hyo Sun, Park, Jung Ho, Kim, Hong Joo, Cho, Yong Kyun, Sohn, Chong Il, Jeon, Woo Kyu, Kim, Byung Ik
Format: Article
Language:English
Subjects:
Adult
Analysis
Anemia
Anemia - complications
Biochemistry
Biomarkers - blood
Blood cell count
Blood Sedimentation
C-reactive protein
C-Reactive Protein - analysis
Care and treatment
Colitis, Ulcerative - blood
Colitis, Ulcerative - complications
Colitis, Ulcerative - pathology
Crohn Disease - blood
Crohn Disease - complications
Crohn Disease - pathology
Erythrocyte Indices
Female
Gastroenterology
Hemoglobin
Hemoglobins - analysis
Hepatology
Humans
Inflammation
Inflammatory bowel disease
Leukocyte Count
Male
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Middle Aged
Oncology
Original Article
Sensitivity and Specificity
Transplant Surgery
Ulcerative colitis
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Summary:Background Recent studies have suggested that a higher red blood cell distribution width (RDW) is associated with disease activity in patients with inflammatory bowel disease (IBD). However, the RDW in IBD patients without anemia has not been investigated. Aim This study aimed to determine whether or not RDW could be used for the assessment of disease activity in IBD patients with and without anemia. Methods The serum C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), hemoglobin concentration, platelet and white blood cell counts, and RDW were assessed in 221 IBD patients, comprised of 120 patients with ulcerative colitis (UC) and 101 patients with Crohn’s disease (CD). Disease activity was determined for UC and CD with the Mayo score and the Crohn’s disease activity index, respectively. Results The CRP level, ESR, hemoglobin concentration, hematocrit, and RDW increased according to disease activity in patients with and without anemia (all P  
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-011-1978-2