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Association Between Red Cell Distribution Width and Disease Activity in Patients with Inflammatory Bowel Disease
Background Recent studies have suggested that a higher red blood cell distribution width (RDW) is associated with disease activity in patients with inflammatory bowel disease (IBD). However, the RDW in IBD patients without anemia has not been investigated. Aim This study aimed to determine whether o...
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| Published in: | Digestive diseases and sciences 2012-04, Vol.57 (4), p.1033-1038 |
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| container_issue | 4 |
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| container_title | Digestive diseases and sciences |
| container_volume | 57 |
| creator | Song, Chang Seok Park, Dong Il Yoon, Min Yong Seok, Hyo Sun Park, Jung Ho Kim, Hong Joo Cho, Yong Kyun Sohn, Chong Il Jeon, Woo Kyu Kim, Byung Ik |
| description | Background
Recent studies have suggested that a higher red blood cell distribution width (RDW) is associated with disease activity in patients with inflammatory bowel disease (IBD). However, the RDW in IBD patients without anemia has not been investigated.
Aim
This study aimed to determine whether or not RDW could be used for the assessment of disease activity in IBD patients with and without anemia.
Methods
The serum C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), hemoglobin concentration, platelet and white blood cell counts, and RDW were assessed in 221 IBD patients, comprised of 120 patients with ulcerative colitis (UC) and 101 patients with Crohn’s disease (CD). Disease activity was determined for UC and CD with the Mayo score and the Crohn’s disease activity index, respectively.
Results
The CRP level, ESR, hemoglobin concentration, hematocrit, and RDW increased according to disease activity in patients with and without anemia (all
P
|
| doi_str_mv | 10.1007/s10620-011-1978-2 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_929120206</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A712948816</galeid><sourcerecordid>A712948816</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-b88bab457500b09237921245c87716a29a9832b2b9a2df7a76c16bd4bf767d8b3</originalsourceid><addsrcrecordid>eNp9kl1vFCEUhonR2G31B3hjiF7ozVQOO8PH5Xb9atJEYzReEphhKs0MbIFxs_--jNNqNGq4gBye94UXDkJPgJwCIfxVAsIoqQhABZKLit5DK2j4uqINE_fRigArawB2hI5TuiKESA7sITqiFGpOa7ZCu01KoXU6u-Dxmc17az3-ZDu8tcOAX7uUozPTj92vrsvfsPbdXLY6Wbxps_vu8gE7jz8WC-tzwntXqHPfD3ocdQ7xgM_C3g53okfoQa-HZB_fzifoy9s3n7fvq4sP7863m4uqrTnJlRHCaFM3vCHEEEnXXFKgddMKXiJoKrUUa2qokZp2PdectcBMV5ueM94Jsz5BLxbfXQzXk01ZjS61JZT2NkxJSSqBEkpYIV_-lwRZl_fiDfCCPvsDvQpT9CVH8RNc1GtoCvR8gS71YJXzfchRt7On2nCgshYC5lNP_0KV0dnRtcHb3pX6bwJYBG0MKUXbq110o44HBUTN7aCWdlClHdTcDooWzdPb-05mtN1Pxd3_F4AuQCpb_tLGX4H-7XoDqpq9DQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>928784315</pqid></control><display><type>article</type><title>Association Between Red Cell Distribution Width and Disease Activity in Patients with Inflammatory Bowel Disease</title><source>Springer Nature</source><creator>Song, Chang Seok ; Park, Dong Il ; Yoon, Min Yong ; Seok, Hyo Sun ; Park, Jung Ho ; Kim, Hong Joo ; Cho, Yong Kyun ; Sohn, Chong Il ; Jeon, Woo Kyu ; Kim, Byung Ik</creator><creatorcontrib>Song, Chang Seok ; Park, Dong Il ; Yoon, Min Yong ; Seok, Hyo Sun ; Park, Jung Ho ; Kim, Hong Joo ; Cho, Yong Kyun ; Sohn, Chong Il ; Jeon, Woo Kyu ; Kim, Byung Ik</creatorcontrib><description>Background
Recent studies have suggested that a higher red blood cell distribution width (RDW) is associated with disease activity in patients with inflammatory bowel disease (IBD). However, the RDW in IBD patients without anemia has not been investigated.
Aim
This study aimed to determine whether or not RDW could be used for the assessment of disease activity in IBD patients with and without anemia.
Methods
The serum C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), hemoglobin concentration, platelet and white blood cell counts, and RDW were assessed in 221 IBD patients, comprised of 120 patients with ulcerative colitis (UC) and 101 patients with Crohn’s disease (CD). Disease activity was determined for UC and CD with the Mayo score and the Crohn’s disease activity index, respectively.
Results
The CRP level, ESR, hemoglobin concentration, hematocrit, and RDW increased according to disease activity in patients with and without anemia (all
P
< 0.05). Multivariate analysis demonstrated that RDW was the best independent indicator for predicting disease activity in CD patients without anemia [odd ratios (OR), 1.702; 95% confidence interval (CI), 1.185–2.445;
P
= 0.004] and UC patients without anemia (OR, 4.921; 95% CI, 2.281–10.615;
P
< 0.001). Also, ROC curve analysis showed the RDW to be the most significant indicator of non-anemic active IBD [area under curve (AUC) in CD, 0.852,
P
< 0.001; AUC in UC, 0.827,
P
< 0.001].
Conclusion
The association between increased RDW and active IBD was evident in IBD patients with and without anemia.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-011-1978-2</identifier><identifier>PMID: 22147246</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Analysis ; Anemia ; Anemia - complications ; Biochemistry ; Biomarkers - blood ; Blood cell count ; Blood Sedimentation ; C-reactive protein ; C-Reactive Protein - analysis ; Care and treatment ; Colitis, Ulcerative - blood ; Colitis, Ulcerative - complications ; Colitis, Ulcerative - pathology ; Crohn Disease - blood ; Crohn Disease - complications ; Crohn Disease - pathology ; Erythrocyte Indices ; Female ; Gastroenterology ; Hemoglobin ; Hemoglobins - analysis ; Hepatology ; Humans ; Inflammation ; Inflammatory bowel disease ; Leukocyte Count ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Oncology ; Original Article ; Sensitivity and Specificity ; Transplant Surgery ; Ulcerative colitis</subject><ispartof>Digestive diseases and sciences, 2012-04, Vol.57 (4), p.1033-1038</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><rights>COPYRIGHT 2012 Springer</rights><rights>Springer Science+Business Media, LLC 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-b88bab457500b09237921245c87716a29a9832b2b9a2df7a76c16bd4bf767d8b3</citedby><cites>FETCH-LOGICAL-c470t-b88bab457500b09237921245c87716a29a9832b2b9a2df7a76c16bd4bf767d8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22147246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Chang Seok</creatorcontrib><creatorcontrib>Park, Dong Il</creatorcontrib><creatorcontrib>Yoon, Min Yong</creatorcontrib><creatorcontrib>Seok, Hyo Sun</creatorcontrib><creatorcontrib>Park, Jung Ho</creatorcontrib><creatorcontrib>Kim, Hong Joo</creatorcontrib><creatorcontrib>Cho, Yong Kyun</creatorcontrib><creatorcontrib>Sohn, Chong Il</creatorcontrib><creatorcontrib>Jeon, Woo Kyu</creatorcontrib><creatorcontrib>Kim, Byung Ik</creatorcontrib><title>Association Between Red Cell Distribution Width and Disease Activity in Patients with Inflammatory Bowel Disease</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background
Recent studies have suggested that a higher red blood cell distribution width (RDW) is associated with disease activity in patients with inflammatory bowel disease (IBD). However, the RDW in IBD patients without anemia has not been investigated.
Aim
This study aimed to determine whether or not RDW could be used for the assessment of disease activity in IBD patients with and without anemia.
Methods
The serum C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), hemoglobin concentration, platelet and white blood cell counts, and RDW were assessed in 221 IBD patients, comprised of 120 patients with ulcerative colitis (UC) and 101 patients with Crohn’s disease (CD). Disease activity was determined for UC and CD with the Mayo score and the Crohn’s disease activity index, respectively.
Results
The CRP level, ESR, hemoglobin concentration, hematocrit, and RDW increased according to disease activity in patients with and without anemia (all
P
< 0.05). Multivariate analysis demonstrated that RDW was the best independent indicator for predicting disease activity in CD patients without anemia [odd ratios (OR), 1.702; 95% confidence interval (CI), 1.185–2.445;
P
= 0.004] and UC patients without anemia (OR, 4.921; 95% CI, 2.281–10.615;
P
< 0.001). Also, ROC curve analysis showed the RDW to be the most significant indicator of non-anemic active IBD [area under curve (AUC) in CD, 0.852,
P
< 0.001; AUC in UC, 0.827,
P
< 0.001].
Conclusion
The association between increased RDW and active IBD was evident in IBD patients with and without anemia.</description><subject>Adult</subject><subject>Analysis</subject><subject>Anemia</subject><subject>Anemia - complications</subject><subject>Biochemistry</subject><subject>Biomarkers - blood</subject><subject>Blood cell count</subject><subject>Blood Sedimentation</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Care and treatment</subject><subject>Colitis, Ulcerative - blood</subject><subject>Colitis, Ulcerative - complications</subject><subject>Colitis, Ulcerative - pathology</subject><subject>Crohn Disease - blood</subject><subject>Crohn Disease - complications</subject><subject>Crohn Disease - pathology</subject><subject>Erythrocyte Indices</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Hemoglobin</subject><subject>Hemoglobins - analysis</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammatory bowel disease</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Sensitivity and Specificity</subject><subject>Transplant Surgery</subject><subject>Ulcerative colitis</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kl1vFCEUhonR2G31B3hjiF7ozVQOO8PH5Xb9atJEYzReEphhKs0MbIFxs_--jNNqNGq4gBye94UXDkJPgJwCIfxVAsIoqQhABZKLit5DK2j4uqINE_fRigArawB2hI5TuiKESA7sITqiFGpOa7ZCu01KoXU6u-Dxmc17az3-ZDu8tcOAX7uUozPTj92vrsvfsPbdXLY6Wbxps_vu8gE7jz8WC-tzwntXqHPfD3ocdQ7xgM_C3g53okfoQa-HZB_fzifoy9s3n7fvq4sP7863m4uqrTnJlRHCaFM3vCHEEEnXXFKgddMKXiJoKrUUa2qokZp2PdectcBMV5ueM94Jsz5BLxbfXQzXk01ZjS61JZT2NkxJSSqBEkpYIV_-lwRZl_fiDfCCPvsDvQpT9CVH8RNc1GtoCvR8gS71YJXzfchRt7On2nCgshYC5lNP_0KV0dnRtcHb3pX6bwJYBG0MKUXbq110o44HBUTN7aCWdlClHdTcDooWzdPb-05mtN1Pxd3_F4AuQCpb_tLGX4H-7XoDqpq9DQ</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Song, Chang Seok</creator><creator>Park, Dong Il</creator><creator>Yoon, Min Yong</creator><creator>Seok, Hyo Sun</creator><creator>Park, Jung Ho</creator><creator>Kim, Hong Joo</creator><creator>Cho, Yong Kyun</creator><creator>Sohn, Chong Il</creator><creator>Jeon, Woo Kyu</creator><creator>Kim, Byung Ik</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20120401</creationdate><title>Association Between Red Cell Distribution Width and Disease Activity in Patients with Inflammatory Bowel Disease</title><author>Song, Chang Seok ; Park, Dong Il ; Yoon, Min Yong ; Seok, Hyo Sun ; Park, Jung Ho ; Kim, Hong Joo ; Cho, Yong Kyun ; Sohn, Chong Il ; Jeon, Woo Kyu ; Kim, Byung Ik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-b88bab457500b09237921245c87716a29a9832b2b9a2df7a76c16bd4bf767d8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Anemia</topic><topic>Anemia - complications</topic><topic>Biochemistry</topic><topic>Biomarkers - blood</topic><topic>Blood cell count</topic><topic>Blood Sedimentation</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Care and treatment</topic><topic>Colitis, Ulcerative - blood</topic><topic>Colitis, Ulcerative - complications</topic><topic>Colitis, Ulcerative - pathology</topic><topic>Crohn Disease - blood</topic><topic>Crohn Disease - complications</topic><topic>Crohn Disease - pathology</topic><topic>Erythrocyte Indices</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Hemoglobin</topic><topic>Hemoglobins - analysis</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammatory bowel disease</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Sensitivity and Specificity</topic><topic>Transplant Surgery</topic><topic>Ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Chang Seok</creatorcontrib><creatorcontrib>Park, Dong Il</creatorcontrib><creatorcontrib>Yoon, Min Yong</creatorcontrib><creatorcontrib>Seok, Hyo Sun</creatorcontrib><creatorcontrib>Park, Jung Ho</creatorcontrib><creatorcontrib>Kim, Hong Joo</creatorcontrib><creatorcontrib>Cho, Yong Kyun</creatorcontrib><creatorcontrib>Sohn, Chong Il</creatorcontrib><creatorcontrib>Jeon, Woo Kyu</creatorcontrib><creatorcontrib>Kim, Byung Ik</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Databases</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Chang Seok</au><au>Park, Dong Il</au><au>Yoon, Min Yong</au><au>Seok, Hyo Sun</au><au>Park, Jung Ho</au><au>Kim, Hong Joo</au><au>Cho, Yong Kyun</au><au>Sohn, Chong Il</au><au>Jeon, Woo Kyu</au><au>Kim, Byung Ik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Red Cell Distribution Width and Disease Activity in Patients with Inflammatory Bowel Disease</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>57</volume><issue>4</issue><spage>1033</spage><epage>1038</epage><pages>1033-1038</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Background
Recent studies have suggested that a higher red blood cell distribution width (RDW) is associated with disease activity in patients with inflammatory bowel disease (IBD). However, the RDW in IBD patients without anemia has not been investigated.
Aim
This study aimed to determine whether or not RDW could be used for the assessment of disease activity in IBD patients with and without anemia.
Methods
The serum C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), hemoglobin concentration, platelet and white blood cell counts, and RDW were assessed in 221 IBD patients, comprised of 120 patients with ulcerative colitis (UC) and 101 patients with Crohn’s disease (CD). Disease activity was determined for UC and CD with the Mayo score and the Crohn’s disease activity index, respectively.
Results
The CRP level, ESR, hemoglobin concentration, hematocrit, and RDW increased according to disease activity in patients with and without anemia (all
P
< 0.05). Multivariate analysis demonstrated that RDW was the best independent indicator for predicting disease activity in CD patients without anemia [odd ratios (OR), 1.702; 95% confidence interval (CI), 1.185–2.445;
P
= 0.004] and UC patients without anemia (OR, 4.921; 95% CI, 2.281–10.615;
P
< 0.001). Also, ROC curve analysis showed the RDW to be the most significant indicator of non-anemic active IBD [area under curve (AUC) in CD, 0.852,
P
< 0.001; AUC in UC, 0.827,
P
< 0.001].
Conclusion
The association between increased RDW and active IBD was evident in IBD patients with and without anemia.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22147246</pmid><doi>10.1007/s10620-011-1978-2</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 2012-04, Vol.57 (4), p.1033-1038 |
| issn | 0163-2116 1573-2568 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_929120206 |
| source | Springer Nature |
| subjects | Adult Analysis Anemia Anemia - complications Biochemistry Biomarkers - blood Blood cell count Blood Sedimentation C-reactive protein C-Reactive Protein - analysis Care and treatment Colitis, Ulcerative - blood Colitis, Ulcerative - complications Colitis, Ulcerative - pathology Crohn Disease - blood Crohn Disease - complications Crohn Disease - pathology Erythrocyte Indices Female Gastroenterology Hemoglobin Hemoglobins - analysis Hepatology Humans Inflammation Inflammatory bowel disease Leukocyte Count Male Medical research Medicine Medicine & Public Health Medicine, Experimental Middle Aged Oncology Original Article Sensitivity and Specificity Transplant Surgery Ulcerative colitis |
| title | Association Between Red Cell Distribution Width and Disease Activity in Patients with Inflammatory Bowel Disease |
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