Outwitting Evolution: Fighting Drug-Resistant TB, Malaria, and HIV

Although caused by vastly different pathogens, the world's three most serious infectious diseases, tuberculosis, malaria, and HIV-1 infection, share the common problem of drug resistance. The pace of drug development has been very slow for tuberculosis and malaria and rapid for HIV-1. But for e...

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Bibliographic Details
Published in:Cell 2012-03, Vol.148 (6), p.1271-1283
Main Authors: Goldberg, Daniel E., Siliciano, Robert F., Jacobs, William R.
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Drug Resistance
drugs
evolution
HIV infections
HIV Infections - drug therapy
HIV Infections - virology
HIV-1 - drug effects
Human immunodeficiency virus 1
Humans
malaria
Malaria - drug therapy
Malaria - parasitology
Mycobacterium
Mycobacterium tuberculosis - drug effects
pathogens
Plasmodium - drug effects
tuberculosis
Tuberculosis - drug therapy
Tuberculosis - microbiology
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Description
Summary:Although caused by vastly different pathogens, the world's three most serious infectious diseases, tuberculosis, malaria, and HIV-1 infection, share the common problem of drug resistance. The pace of drug development has been very slow for tuberculosis and malaria and rapid for HIV-1. But for each disease, resistance to most drugs has appeared quickly after the introduction of the drug. Learning how to manage and prevent resistance is a major medical challenge that requires an understanding of the evolutionary dynamics of each pathogen. This Review summarizes the similarities and differences in the evolution of drug resistance for these three pathogens.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2012.02.021