Infection by Cag A positive strains of Helicobacter pylori is associated with autoimmune thyroid disease in Iranian patients

Infectious agents have been suspected as a triggering factor for development of autoimmune thyroid disease (ATD). Some reports from Western countries have suggested association between Helicobacter pylori (HP) infection and ATD. To investigate the association of ATD with Cag A seropositivity in a po...

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Bibliographic Details
Published in:Iranian journal of immunology 2012-03, Vol.9 (1), p.48-52
Main Authors: Soveid, Mahmood, Hosseini Asl, Kazem, Omrani, Gholamhossein Ranjbar
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies, Bacterial - immunology
Antigens, Bacterial - immunology
Autoimmune Diseases - immunology
Autoimmune Diseases - microbiology
Bacterial Proteins - immunology
Female
Graves Disease - immunology
Graves Disease - microbiology
Helicobacter Infections - immunology
Helicobacter Infections - microbiology
Helicobacter pylori - immunology
Helicobacter pylori - physiology
Host-Pathogen Interactions - immunology
Humans
Hypothyroidism - immunology
Hypothyroidism - microbiology
Immunoglobulin G - immunology
Iran
Male
Middle Aged
Thyroid Diseases - immunology
Thyroid Diseases - microbiology
Young Adult
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Summary:Infectious agents have been suspected as a triggering factor for development of autoimmune thyroid disease (ATD). Some reports from Western countries have suggested association between Helicobacter pylori (HP) infection and ATD. To investigate the association of ATD with Cag A seropositivity in a population with high rate and early age of onset of HP infection. IgG anti HP and anti Cag A antibodies were measured in 88 patients with ATD and compared with results of 112 healthy individuals. The rate of infection with HP was not significantly different in patient and control groups, but there was significant association between ATD and infection with Cag A strains (p
ISSN:1735-367X