Associations of Maternal Prepregnancy Body Mass Index and Gestational Weight Gain With Adult Offspring Cardiometabolic Risk Factors: The Jerusalem Perinatal Family Follow-Up Study

Accumulating evidence demonstrates that both maternal prepregnancy body mass index (mppBMI) and gestational weight gain (GWG) are associated with adult offspring adiposity. However, whether these maternal attributes are related to other cardiometabolic risk factors in adulthood has not been comprehe...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2012-03, Vol.125 (11), p.1381-1389
Main Authors: HOCHNER, Hagit, FRIEDLANDER, Yechiel, CALDERON-MARGALIT, Ronit, MEINER, Vardiella, SAGY, Yael, AVGIL-TSADOK, Meytal, BURGER, Ayala, SAVITSKY, Bella, SISCOVICK, David S, MANOR, Orly
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adult Children
Biological and medical sciences
Birth Weight - physiology
Blood and lymphatic vessels
Blood. Blood coagulation. Reticuloendothelial system
Body Mass Index
Cardiology. Vascular system
Cardiovascular Diseases - blood
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - physiopathology
Cohort Studies
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Follow-Up Studies
Humans
Infant, Newborn
Israel - epidemiology
Male
Medical sciences
Metabolic Networks and Pathways - physiology
Pharmacology. Drug treatments
Pregnancy
Prenatal Care - methods
Prospective Studies
Risk Factors
Weight Gain - physiology
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Summary:Accumulating evidence demonstrates that both maternal prepregnancy body mass index (mppBMI) and gestational weight gain (GWG) are associated with adult offspring adiposity. However, whether these maternal attributes are related to other cardiometabolic risk factors in adulthood has not been comprehensively studied. We used a birth cohort of 1400 young adults born in Jerusalem who had extensive archival data and clinical information at 32 years of age to prospectively examine the associations of mppBMI and GWG with adiposity and related cardiometabolic outcomes. Greater mppBMI, independently of GWG and confounders, was significantly associated with higher offspring BMI, waist circumference, systolic and diastolic blood pressures, insulin, and triglycerides and with lower high-density lipoprotein cholesterol. For example, the effect sizes were translated to nearly 5 kg/m(2) higher mean BMI, 8.4 cm higher waist circumference, 0.13 mmol/L (11.4 mg/dL) higher triglycerides, and 0.10 mmol/L (3.8 mg/dL) lower high-density lipoprotein cholesterol among offspring of mothers within the upper mppBMI quartile (mppBMI >26.4 kg/m(2)) compared with the lower quartile (mppBMI 14 kg) and lower (GWG
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.111.070060