Toxicology of nanoparticles

While nanotechnology and the production of nanoparticles are growing exponentially, research into the toxicological impact and possible hazard of nanoparticles to human health and the environment is still in its infancy. This review aims to give a comprehensive summary of what is known today about n...

Full description

Saved in:
Bibliographic Details
Published in:Advanced drug delivery reviews 2012-02, Vol.64 (2), p.129-137
Main Authors: Elsaesser, Andreas, Howard, C. Vyvyan
Format: Article
Language:English
Subjects:
Agglomeration
Dose
Entry routes
Environmental Pollutants - chemistry
Environmental Pollutants - toxicity
Hazard identification
Humans
Inflammation
Nanoparticle characterisation
Nanoparticles - chemistry
Nanoparticles - toxicity
Nanotoxicology
Particle Size
Reactive oxygen
Risk assessment
Surface
Surface Properties
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:While nanotechnology and the production of nanoparticles are growing exponentially, research into the toxicological impact and possible hazard of nanoparticles to human health and the environment is still in its infancy. This review aims to give a comprehensive summary of what is known today about nanoparticle toxicology, the mechanisms at the cellular level, entry routes into the body and possible impacts to public health. Proper characterisation of the nanomaterial, as well as understanding processes happening on the nanoparticle surface when in contact with living systems, is crucial to understand possible toxicological effects. Dose as a key parameter is essential in hazard identification and risk assessment of nanotechnologies. Understanding nanoparticle pathways and entry routes into the body requires further research in order to inform policy makers and regulatory bodies about the nanotoxicological potential of certain nanomaterials. [Display omitted]
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2011.09.001