Salivary bone turnover markers in healthy pre- and postmenopausal women: daily and seasonal rhythm

No studies had investigated circadian and circannual rhythms of bone biomarkers in whole saliva. We evaluated the salivary daily and seasonal rhythm of carboxy-terminal telopeptide of type I collagen (CTX) and bone alkaline phosphatase (b-ALP). Forty clinical and oral healthy ambulatory pre- and pos...

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Bibliographic Details
Published in:Clinical oral investigations 2012-04, Vol.16 (2), p.651-657
Main Authors: Pellegrini, Gretel G., Gonzales Chaves, Macarena M. S., Fajardo, Maria A., Ponce, Graciela M., Toyos, Gloria I., Lifshitz, Fima, Friedman, Silvia M., Zeni, Susana N.
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Adult
Alkaline phosphatase
Alkaline Phosphatase - analysis
Alkaline Phosphatase - blood
biomarkers
Biomarkers - analysis
Biomarkers - blood
Biomarkers - urine
Bone diseases
Bone Remodeling - physiology
Bone turnover
Calcium - blood
Circadian Rhythm
Circadian rhythms
Circannual rhythms
Collagen
Collagen (type I)
Collagen Type I - analysis
Collagen Type I - blood
Collagen Type I - urine
Dentistry
Female
Humans
Medicine
Middle Aged
Original Article
Parathyroid Hormone - blood
Peptides - analysis
Peptides - blood
Peptides - urine
Phosphorus - blood
Post-menopause
Postmenopause - blood
Postmenopause - metabolism
Postmenopause - urine
Premenopause - blood
Premenopause - metabolism
Premenopause - urine
Saliva
Salivary Proteins and Peptides - analysis
Seasons
Urine
Vitamin D - analogs & derivatives
Vitamin D - blood
Winter
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Summary:No studies had investigated circadian and circannual rhythms of bone biomarkers in whole saliva. We evaluated the salivary daily and seasonal rhythm of carboxy-terminal telopeptide of type I collagen (CTX) and bone alkaline phosphatase (b-ALP). Forty clinical and oral healthy ambulatory pre- and postmenopausal women from two southern Argentine cities: Comodoro Rivadavia (latitude 45º S) and Ushuaia (latitude 54º S) were included in the study. CTX levels were evaluated in serum, urine, and saliva, and b-ALP levels were measured in serum and saliva. In both groups of women, salivary CTX showed a maximum percentage of change early in the morning (80%) and a minimum in the late afternoon (45%), similarly to the pattern observed in urinary samples. No daily rhythm was observed in serum or salivary b-ALP. 25-Hydroxyvitamin D levels decreased in winter vs. summer ( p  
ISSN:1432-6981
1436-3771
DOI:10.1007/s00784-011-0538-7