Relationships between lumbar bone mineral density and biochemical parameters in phenylketonuria patients

The etiology of reduced bone mineral density (BMD) in phenylketonuria (PKU) is unknown. Reduced BMD may be inherent to PKU and/or secondary to its dietary treatment. Lumbar BMD was measured by dual-energy X-ray absorptiometry in 53 early and continuously treated PKU patients (median age 16, range 2–...

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Bibliographic Details
Published in:Molecular genetics and metabolism 2012-04, Vol.105 (4), p.566-570
Main Authors: de Groot, Martijn J., Hoeksma, Marieke, van Rijn, Margreet, Slart, Riemer H.J.A., van Spronsen, Francjan J.
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Adolescent
Adult
Age
Alkaline phosphatase
Alkaline Phosphatase - metabolism
Blood
BMD
Bone Density
Bone mineral density
Bone turnover
Calcium (blood)
Calcium - metabolism
Child
Child, Preschool
Cross-Sectional Studies
Diet
Dual energy X-ray absorptiometry
DXA
Etiology
Female
Humans
Infant
Infant, Newborn
Lumbar Vertebrae - metabolism
Male
Phenylalanine
Phenylalanine - blood
Phenylketonuria
Phenylketonurias - physiopathology
Phosphorus
PKU
Retrospective Studies
Scanning
Vitamin B 12 Deficiency
Vitamin B12
Young Adult
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Summary:The etiology of reduced bone mineral density (BMD) in phenylketonuria (PKU) is unknown. Reduced BMD may be inherent to PKU and/or secondary to its dietary treatment. Lumbar BMD was measured by dual-energy X-ray absorptiometry in 53 early and continuously treated PKU patients (median age 16, range 2–35years). First, Z-scores of BMD were correlated to age group, clinical severity of PKU, mean phenylalanine (Phe) concentration and Phe variation in the year prior to DXA scanning, as well as to blood vitamin, mineral, and alkaline phosphatase concentrations. Second, parameters were compared between subjects with reduced BMD (Z-score
ISSN:1096-7192
1096-7206
DOI:10.1016/j.ymgme.2012.01.006