Human milk and formulae: Neurotrophic and new biological factors

Abstract Mother milk is widely accepted to be a unique product believed to contain biological factors involved in the regulation of newborn optimal growth including brain when compared to milk-formula milks. In this setting, there is growing evidence that in milk-formula neuro-oxidative stress bioma...

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Bibliographic Details
Published in:Early human development 2012-03, Vol.88, p.S9-S12
Main Authors: Serpero, Laura D, Frigiola, Alessandro, Gazzolo, Diego
Format: Article
Language:English
Subjects:
Activin A
Activins
Advanced Basic Science
Biological and medical sciences
Biological Factors - metabolism
Biomarkers - metabolism
Brain development
Calcium-Binding Proteins - metabolism
Embryology: invertebrates and vertebrates. Teratology
Feeding
Fundamental and applied biological sciences. Psychology
Heat-Shock Proteins - metabolism
Heme Oxygenase-1
HO-1
Humans
Infant Formula - chemistry
Infant, Newborn
Milk
Milk, Human - chemistry
Milk-formulae
Neonatal and Perinatal Medicine
Nerve Growth Factors - metabolism
Newborn
Oxidative Stress - physiology
S100 Calcium Binding Protein beta Subunit
S100 Proteins
S100B
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Summary:Abstract Mother milk is widely accepted to be a unique product believed to contain biological factors involved in the regulation of newborn optimal growth including brain when compared to milk-formula milks. In this setting, there is growing evidence that in milk-formula neuro-oxidative stress biomarkers, neurotrophic proteins and calcium binding proteins, known to be involved in a cascade of events leading to brain, cardiac and vascular development/damage, are to date lacking or at a lower concentration than breast milk. Therefore, this review is aimed at offering additional insights to the role in human milk of some selected biomarkers such as: i) neurotrophic factors such as Activin A; ii) Calcium binding protein such as S100B and, iii) heat shock protein known to be involved in oxidative stress response (namely hemeoxygenase-1, HO-1 or Heat shock Protein 32, HSP32).
ISSN:0378-3782
1872-6232
DOI:10.1016/j.earlhumdev.2011.12.021