Bronchomalacia in Dogs with Myxomatous Mitral Valve Degeneration

• Published in: Journal of veterinary internal medicine 2012-03, Vol.26 (2), p.312-319
• Main Authors: Singh, M.K., Johnson, L.R., Kittleson, M.D., Pollard, R.E.
• Format: Article
• Language: English
• Subjects: Airway collapse; Animals; Bronchoalveolar Lavage Fluid - cytology; Bronchomalacia - complications; Bronchomalacia - diagnostic imaging; Bronchomalacia - physiopathology; Bronchomalacia - veterinary; Bronchoscopy - veterinary; Chronic bronchitis; Cough - physiopathology; Cough - veterinary; Dog Diseases - diagnostic imaging; Dog Diseases - physiopathology; Dogs; Echocardiography - veterinary; Left atrial enlargement; Male; Mitral Valve Insufficiency - complications; Mitral Valve Insufficiency - diagnostic imaging; Mitral Valve Insufficiency - physiopathology; Mitral Valve Insufficiency - veterinary; Radiography
• ISSN: 0891-6640; 1939-1676
• DOI: 10.1111/j.1939-1676.2012.00887.x

Background Cough in the geriatric small breed dog with myxomatous mitral valve degeneration (MMVD), a large left atrium, and absence of heart failure often is attributed to compression of the left mainstem bronchus by the left atrium. Studies investigating this syndrome are lacking in dogs. Hypothesis Airway collapse is independent of left atrial enlargement. Animals A total of 16 dogs presenting with chronic cough in the absence of congestive heart failure. Group 1 dogs (n = 10) had moderate‐to‐severe left atrial enlargement based on an echocardiographically calculated left atrial:aortic surface area [LA:Ao(a)] > 6. Group 2 dogs (n = 6) had no to mild left atrial enlargement [LA:Ao(a) ≤ 6]. Methods Dogs were prospectively evaluated. CBC, biochemistry, urinalysis, cervical and thoracic radiographs, fluoroscopy, echocardiography, and bronchoscopy were performed. Bronchoscopic abnormalities were compared between groups using Fisher's Exact Test. P 50% was observed in multiple bronchi with no difference between groups. All dogs had inflammation on airway cytology with respiratory infection in 1 dog in group 2. Left atrial size was interpreted radiographically as enlarged in 9 of 10 group 1 dog and in 2 of 6 group 2 dogs. VHS was above normal in both groups of dogs regardless of echocardiographic evidence of cardiomegaly. Conclusions Results failed to identify an association between left atrial enlargement and airway collapse in dogs with MMVD, but did suggest that airway inflammation is common in dogs with airway collapse.