Allergy to goat's and sheep's milk in a population of cow's milk-allergic children treated with oral immunotherapy

• Published in: Pediatric allergy and immunology 2012-03, Vol.23 (2), p.128-132
• Main Authors: Rodríguez del Río, Pablo, Sánchez-García, Silvia, Escudero, Carmelo, Pastor-Vargas, Carlos, Sánchez Hernández, José J., Pérez-Rangel, Inmaculada, Ibáñez, María Dolores
• Format: Article
• Language: English
• Subjects: Administration, Oral; Allergic diseases; Anaphylaxis; Animals; Biological and medical sciences; Casein; Cattle; Child; Children; Cow's milk; Cross-reactivity; Data processing; Decision making; Desensitization, Immunologic; Digestive allergic diseases; Enzyme-Linked Immunosorbent Assay; Female; food allergy; Fundamental and applied biological sciences. Psychology; Fundamental immunology; General aspects; goat's milk; Goats; Humans; Hypersensitivity; Immunoassays; Immunoglobulin E; Immunological tolerance; Immunopathology; Immunotherapy; Male; Medical sciences; Milk; Milk Hypersensitivity - epidemiology; Milk Hypersensitivity - etiology; Milk Hypersensitivity - prevention & control; Milk Proteins - adverse effects; Milk Proteins - immunology; Prevalence; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Sheep; sheep's milk; Skin Tests; Statistical analysis
• ISSN: 0905-6157; 1399-3038
• DOI: 10.1111/j.1399-3038.2012.01284.x

To cite this article: Rodríguez del Río P, Sánchez‐García S, Escudero C, Pastor‐Vargas C, Sánchez Hernández JJ, Pérez‐Rangel I, Ibáñez MD. Allergy to goat’s and sheep’s milk in a population of cow’s milk–allergic children treated with oral immunotherapy. Pediatr Allergy Immunol 2012: 23: 128–132. Background:  Cow’s milk oral immunotherapy (CMOIT) is a recognized treatment for persistent cow’s milk (CM) allergy. However, further data are necessary on tolerance to milk from other mammals. Objective:  To describe the clinical and immunologic features of goat’s and sheep’s milk (GSM) allergy in patients who tolerated CM after CMOIT. Methods:  Fifty‐eight CM‐allergic patients who successfully underwent CMOIT in our department were evaluated using skin prick test (SPT), specific immunoglobulin (Ig) E determination, enzyme‐linked immunoassay (ELISA), and controlled oral challenge to assess allergy to GSM. Statistical analysis was carried out to identify markers of allergy to GSM. Results:  Fifteen of 58 (25.9%) patients were allergic to either goat’s or sheep’s milk or to both, as confirmed by a controlled positive oral challenge. Forty‐seven percent of all positive oral challenges were classified as anaphylactic reactions. Specific IgE to CM casein, goat’s whole milk, and sheep’s whole milk was 13.2, 18.0, and 21.4 kUA/l in the group of GSM‐allergic patients and 6.6, 6.5, and 6.5 kUA/l in the GSM‐non‐allergic patients (p