Overexpression of the chemokine receptors CXCR4, CCR7, CCR9, and CCR10 in human primary cutaneous melanoma: a potential prognostic value for CCR7 and CCR10?

Multiple functional implications have been suggested for a limited number of chemokines and their cognate receptors in melanoma pathogenesis. The purpose of this study was to investigate the potential role of the chemokine receptors CXCR4, CCR7, CCR9, and CCR10 as prognostic markers in human primary...

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Bibliographic Details
Published in:Archives of Dermatological Research 2012-04, Vol.304 (3), p.185-193
Main Authors: Kühnelt-Leddihn, Laura, Müller, Hansgeorg, Eisendle, Klaus, Zelger, Bernhard, Weinlich, Georg
Format: Article
Language:English
Subjects:
Biomarkers - analysis
CC chemokine receptors
CCR7 protein
CCR9 protein
Chemokine receptors
CXCR4 protein
Dermatology
Disease Progression
Female
Humans
Immunohistochemistry
Male
Medicine
Medicine & Public Health
Melanoma
Melanoma - metabolism
Metallothionein
Metallothionein - biosynthesis
Metastases
Original Paper
Prognosis
Receptors, CCR - biosynthesis
Receptors, CCR10 - biosynthesis
Receptors, CCR7 - biosynthesis
Receptors, CXCR4 - biosynthesis
Risk groups
Severity of Illness Index
Skin Neoplasms - metabolism
Survival
Tumors
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Summary:Multiple functional implications have been suggested for a limited number of chemokines and their cognate receptors in melanoma pathogenesis. The purpose of this study was to investigate the potential role of the chemokine receptors CXCR4, CCR7, CCR9, and CCR10 as prognostic markers in human primary cutaneous melanoma. Chemokine receptor expression was analyzed by immunohistochemistry in a total of 38 patients with cutaneous melanoma. Results were statistically correlated with melanoma features and clinical disease progression. No significant correlation between overexpression of CXCR4 or CCR9 and survival or prognosis was found. CCR7 overexpression was associated with significantly lower survival (0.005 log rank) and shorter time to progression (0.009 log rank)—similar to CCR10 overexpression (lower survival: 0.001 log rank, shorter time to progression: 0.002 log rank). In addition, CCR7 overexpression correlated with expression of metallothionein, while CCR10 seems to be associated with cerebral metastases. Two chemokine receptors permitting the identification of high-risk patients were identified: CCR7 and CCR10 overexpressions were found to be associated with a worse outcome of disease course independent of Breslow’s tumor thickness and Clark level, thus representing possible additional prognostic markers.
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-012-1222-8