Current Understanding of Rheumatoid Arthritis Therapy

Progress in understanding the cellular and molecular mechanisms of rheumatoid arthritis (RA), together with the availability of new therapies, has changed the way we think about RA. The paradigm shift in RA therapy has been from controlling symptoms to controlling the disease process with the abroga...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2012-04, Vol.91 (4), p.607-620
Main Authors: Colmegna, I, Ohata, B R, Menard, H A
Format: Article
Language:English
Subjects:
Animals
Antirheumatic Agents - administration & dosage
Antirheumatic Agents - immunology
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - immunology
Arthritis, Rheumatoid - prevention & control
Drug Delivery Systems - methods
Drug Delivery Systems - trends
Humans
Interleukin-6 - antagonists & inhibitors
Signal Transduction - drug effects
Signal Transduction - immunology
Tumor Necrosis Factor-alpha - antagonists & inhibitors
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Summary:Progress in understanding the cellular and molecular mechanisms of rheumatoid arthritis (RA), together with the availability of new therapies, has changed the way we think about RA. The paradigm shift in RA therapy has been from controlling symptoms to controlling the disease process with the abrogation of inflammation. Challenges that are still unresolved include the issues in disease prevention, treatment specificity to restore tolerance, approaches to facilitate tissue repair, and treatment optimization to fit the individual patient's disease phenotype and comorbidity context. This review summarizes the pathogenesis‐related rationales for the current therapeutic strategies in RA and for emerging therapies and potential approaches to restoring immune tolerance in RA. Clinical Pharmacology & Therapeutics (2012); 91 4, 607–620. doi:10.1038/clpt.2011.325
ISSN:0009-9236
1532-6535
DOI:10.1038/clpt.2011.325