Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sympathetic nervous and mucosal immune systems in breast cancer survivors

Abstract Stress can play an important role in development of cancer-related fatigue (CRF) by activating the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic nervous system (SNS), and altering the immune system. This study examined the influence of catechol-O-methyltransferase (COMT) Val158...

Full description

Saved in:
Bibliographic Details
Published in:Breast (Edinburgh) 2012-04, Vol.21 (2), p.199-203
Main Authors: Fernández-de-las-Peñas, César, Cantarero-Villanueva, Irene, Fernández-Lao, Carolina, Ambite-Quesada, Silvia, Díaz-Rodríguez, Lourdes, Rivas-Martínez, Inés, Moral-Avila, Rosario del, Arroyo-Morales, Manuel
Format: Article
Language:English
Subjects:
Adult
alpha-Amylases - analysis
Breast Neoplasms - physiopathology
Breast Neoplasms - psychology
Cancer survivors
Catechol O-Methyltransferase - genetics
Catechol O-Methyltransferase - immunology
Catechol O-Methyltransferase - metabolism
Cortisol
Fatigue
Fatigue - genetics
Female
Genetics
Genotype
Hematology, Oncology and Palliative Medicine
Humans
Hydrocortisone - analysis
Hypothalamo-Hypophyseal System - metabolism
Immunity, Mucosal - genetics
Immunoglobulin A
Immunoglobulin A - analysis
Middle Aged
Pituitary-Adrenal System - metabolism
Saliva - chemistry
Stress, Psychological
Survivors
Sympathetic Nervous System - metabolism
α-amylase
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Stress can play an important role in development of cancer-related fatigue (CRF) by activating the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic nervous system (SNS), and altering the immune system. This study examined the influence of catechol-O-methyltransferase (COMT) Val158Met genotypes on salivary markers of HPA axis (cortisol), SNS ( α -amylase) and immune (IgA) systems, as well as on CRF in breast cancer survivors (BCS). One-hundred BCS participated. After amplifying Val158Met COMT polymorphisms by polymerase chain reaction, three COMT genotypes were considered: Val/Val, Val/Met, Met/Met. Salivary cortisol, α -amylase activity, salivary flow rate, and IgA concentration were collected from non-stimulated saliva. CRF was assessed with the fatigue subscale of the Profile of Mood State (POMS) questionnaire. We found that BCS carrying Met/Met genotype reported higher cortisol concentration, α -amylase activity and greater CRF than those with Val/Met ( P  
ISSN:0960-9776
1532-3080
DOI:10.1016/j.breast.2011.09.012