Premotor signs and symptoms of multiple system atrophy

Summary Diagnostic criteria for multiple system atrophy are focused on motor manifestations of the disease, in particular ataxia and parkinsonism, but these criteria often cannot detect the early stages. Non-motor symptoms and signs of multiple system atrophy often precede the onset of classic motor...

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Bibliographic Details
Published in:Lancet neurology 2012-04, Vol.11 (4), p.361-368
Main Authors: Jecmenica-Lukic, Milica, MD, Poewe, Werner, Prof, Tolosa, Eduardo, Prof, Wenning, Gregor K, Dr, Prof
Format: Article
Language:English
Subjects:
Ataxia
Atrophy
Autonomic nervous system
Basal ganglia
Blood pressure
Central nervous system diseases
Diagnosis, Differential
Erectile dysfunction
Humans
Movement disorders
Multiple System Atrophy - diagnosis
Multiple System Atrophy - physiopathology
Neurology
Neuroprotective agents
Orthostatic hypotension
Parkinson's disease
Pure Autonomic Failure - diagnosis
Pure Autonomic Failure - physiopathology
Sleep disorders
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Summary:Summary Diagnostic criteria for multiple system atrophy are focused on motor manifestations of the disease, in particular ataxia and parkinsonism, but these criteria often cannot detect the early stages. Non-motor symptoms and signs of multiple system atrophy often precede the onset of classic motor manifestations, and this prodromal phase is estimated to last from several months to years. Autonomic failure, sleep problems, and respiratory disturbances are well known symptoms of established multiple system atrophy and, when presenting early and preceding ataxia or parkinsonism, should be regarded as evidence of premotor multiple system atrophy. An early and accurate diagnosis is becoming increasingly important as new neuroprotective agents are developed.
ISSN:1474-4422
1474-4465
DOI:10.1016/S1474-4422(12)70022-4