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Plasma persistence of 2-aminothiazoline-4-carboxylic acid in rat system determined by liquid chromatography tandem mass spectrometry
► ATCA persistence was determined after injecting it directly to the blood stream. ► ATCA concentration in blood decreased to half within 2.5h in the rat system. ► After the initial loss, ATCA level stayed constant (700ng/ml) over 48h. ► Endogenous ATCA level in blood was found 141ng/ml. ► The role...
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| Published in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2012-04, Vol.891-892, p.81-84 |
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| cited_by | cdi_FETCH-LOGICAL-c534t-a6c13c5509afbe85f6fff9b644e73c858da3155f8f15992c57815c05f2453b893 |
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| cites | cdi_FETCH-LOGICAL-c534t-a6c13c5509afbe85f6fff9b644e73c858da3155f8f15992c57815c05f2453b893 |
| container_end_page | 84 |
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| container_start_page | 81 |
| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
| container_volume | 891-892 |
| creator | Petrikovics, Ilona Yu, Jorn C.C. Thompson, David E. Jayanna, Prashanth Logue, Brian A. Nasr, Jessica Bhandari, Raj K. Baskin, Steven I. Rockwood, Gary |
| description | ► ATCA persistence was determined after injecting it directly to the blood stream. ► ATCA concentration in blood decreased to half within 2.5h in the rat system. ► After the initial loss, ATCA level stayed constant (700ng/ml) over 48h. ► Endogenous ATCA level in blood was found 141ng/ml. ► The role of ATCA as a biomarker for CN exposure needs more future investigations.
2-Aminothiazoline-4-carboxylic acid (ATCA) was intravenously injected to rats in order to investigate its plasma distribution. ATCA was extracted from plasma samples by solid phase extraction (SPE) and molecularly imprinted polymer stir bar sorption extraction (MIP-SBSE). Detection and quantification of ATCA were achieved by using liquid chromatography–tandem mass spectrometry (LC–MS/MS). It was found that the intravenously injected ATCA concentration quickly decreased to half within 2.5h in the rat system. However, after 2.5h, the concentration of ATCA in plasma stayed constant at least 5 folds above the endogenous ATCA level for more then 48h. This finding can be used for evaluating ATCA's diagnostic and forensic value as a biomarker for cyanide exposure. |
| doi_str_mv | 10.1016/j.jchromb.2012.01.024 |
| format | article |
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2-Aminothiazoline-4-carboxylic acid (ATCA) was intravenously injected to rats in order to investigate its plasma distribution. ATCA was extracted from plasma samples by solid phase extraction (SPE) and molecularly imprinted polymer stir bar sorption extraction (MIP-SBSE). Detection and quantification of ATCA were achieved by using liquid chromatography–tandem mass spectrometry (LC–MS/MS). It was found that the intravenously injected ATCA concentration quickly decreased to half within 2.5h in the rat system. However, after 2.5h, the concentration of ATCA in plasma stayed constant at least 5 folds above the endogenous ATCA level for more then 48h. This finding can be used for evaluating ATCA's diagnostic and forensic value as a biomarker for cyanide exposure.</description><identifier>ISSN: 1570-0232</identifier><identifier>EISSN: 1873-376X</identifier><identifier>DOI: 10.1016/j.jchromb.2012.01.024</identifier><identifier>PMID: 22386362</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>2-Aminothiazoline-4-carboxylic acid (ATCA) ; Animals ; biomarkers ; Chromatography ; Chromatography, Liquid - methods ; Cyanide exposure ; cyanides ; Diagnostic biomarker ; Diagnostic systems ; Extraction ; Forensic biomarker ; forensic sciences ; Imprinted polymers ; intravenous injection ; LC–MS/MS ; liquid chromatography ; Liquids ; Male ; Mass spectrometry ; molecular imprinting ; polymers ; Rats ; solid phase extraction ; Solid phases ; sorption ; tandem mass spectrometry ; Tandem Mass Spectrometry - methods ; Thiazoles - blood</subject><ispartof>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012-04, Vol.891-892, p.81-84</ispartof><rights>2012 Elsevier B.V.</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-a6c13c5509afbe85f6fff9b644e73c858da3155f8f15992c57815c05f2453b893</citedby><cites>FETCH-LOGICAL-c534t-a6c13c5509afbe85f6fff9b644e73c858da3155f8f15992c57815c05f2453b893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22386362$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petrikovics, Ilona</creatorcontrib><creatorcontrib>Yu, Jorn C.C.</creatorcontrib><creatorcontrib>Thompson, David E.</creatorcontrib><creatorcontrib>Jayanna, Prashanth</creatorcontrib><creatorcontrib>Logue, Brian A.</creatorcontrib><creatorcontrib>Nasr, Jessica</creatorcontrib><creatorcontrib>Bhandari, Raj K.</creatorcontrib><creatorcontrib>Baskin, Steven I.</creatorcontrib><creatorcontrib>Rockwood, Gary</creatorcontrib><title>Plasma persistence of 2-aminothiazoline-4-carboxylic acid in rat system determined by liquid chromatography tandem mass spectrometry</title><title>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</title><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><description>► ATCA persistence was determined after injecting it directly to the blood stream. ► ATCA concentration in blood decreased to half within 2.5h in the rat system. ► After the initial loss, ATCA level stayed constant (700ng/ml) over 48h. ► Endogenous ATCA level in blood was found 141ng/ml. ► The role of ATCA as a biomarker for CN exposure needs more future investigations.
2-Aminothiazoline-4-carboxylic acid (ATCA) was intravenously injected to rats in order to investigate its plasma distribution. ATCA was extracted from plasma samples by solid phase extraction (SPE) and molecularly imprinted polymer stir bar sorption extraction (MIP-SBSE). Detection and quantification of ATCA were achieved by using liquid chromatography–tandem mass spectrometry (LC–MS/MS). It was found that the intravenously injected ATCA concentration quickly decreased to half within 2.5h in the rat system. However, after 2.5h, the concentration of ATCA in plasma stayed constant at least 5 folds above the endogenous ATCA level for more then 48h. This finding can be used for evaluating ATCA's diagnostic and forensic value as a biomarker for cyanide exposure.</description><subject>2-Aminothiazoline-4-carboxylic acid (ATCA)</subject><subject>Animals</subject><subject>biomarkers</subject><subject>Chromatography</subject><subject>Chromatography, Liquid - methods</subject><subject>Cyanide exposure</subject><subject>cyanides</subject><subject>Diagnostic biomarker</subject><subject>Diagnostic systems</subject><subject>Extraction</subject><subject>Forensic biomarker</subject><subject>forensic sciences</subject><subject>Imprinted polymers</subject><subject>intravenous injection</subject><subject>LC–MS/MS</subject><subject>liquid chromatography</subject><subject>Liquids</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>molecular imprinting</subject><subject>polymers</subject><subject>Rats</subject><subject>solid phase extraction</subject><subject>Solid phases</subject><subject>sorption</subject><subject>tandem mass spectrometry</subject><subject>Tandem Mass Spectrometry - methods</subject><subject>Thiazoles - blood</subject><issn>1570-0232</issn><issn>1873-376X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1DAUhSMEoqXwCIB3sEnwT-w4K1RV_EmVQIJK7Kwb57rjURJPbQ8irHlwPMzAEla25O-7vjqnqp4y2jDK1Ktts7WbGOah4ZTxhrKG8vZedc50J2rRqa_3y112tKZc8LPqUUpbSllHO_GwOuNcaCUUP69-fpogzUB2GJNPGReLJDjCa5j9EvLGw48w-QXrtrYQh_B9nbwlYP1I_EIiZJLWos1kxIyxODiSYSWTv9sX5PeGkMNthN1mJRmWsaAzpETSDm0ur5jj-rh64GBK-OR0XlQ3b998uXpfX3989-Hq8rq2UrS5BmWZsFLSHtyAWjrlnOsH1bbYCaulHkEwKZ12TPY9t7LTTFoqHW-lGHQvLqoXx7m7GO72mLKZfbI4TbBg2CfTt1r3spe6kC__STLKeV8Cp6qg8ojaGFKK6Mwu-hniWiBzqMpszakqc6jKUGaKWbxnpy_2w4zjX-tPNwV4fgQcBAO30Sdz87lMUJRS1QkhC_H6SGAJ7ZvHaJL1hwpHH0u6Zgz-P0v8AkAbsyI</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Petrikovics, Ilona</creator><creator>Yu, Jorn C.C.</creator><creator>Thompson, David E.</creator><creator>Jayanna, Prashanth</creator><creator>Logue, Brian A.</creator><creator>Nasr, Jessica</creator><creator>Bhandari, Raj K.</creator><creator>Baskin, Steven I.</creator><creator>Rockwood, Gary</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TB</scope><scope>8FD</scope><scope>FR3</scope><scope>7X8</scope></search><sort><creationdate>20120401</creationdate><title>Plasma persistence of 2-aminothiazoline-4-carboxylic acid in rat system determined by liquid chromatography tandem mass spectrometry</title><author>Petrikovics, Ilona ; Yu, Jorn C.C. ; Thompson, David E. ; Jayanna, Prashanth ; Logue, Brian A. ; Nasr, Jessica ; Bhandari, Raj K. ; Baskin, Steven I. ; Rockwood, Gary</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-a6c13c5509afbe85f6fff9b644e73c858da3155f8f15992c57815c05f2453b893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>2-Aminothiazoline-4-carboxylic acid (ATCA)</topic><topic>Animals</topic><topic>biomarkers</topic><topic>Chromatography</topic><topic>Chromatography, Liquid - methods</topic><topic>Cyanide exposure</topic><topic>cyanides</topic><topic>Diagnostic biomarker</topic><topic>Diagnostic systems</topic><topic>Extraction</topic><topic>Forensic biomarker</topic><topic>forensic sciences</topic><topic>Imprinted polymers</topic><topic>intravenous injection</topic><topic>LC–MS/MS</topic><topic>liquid chromatography</topic><topic>Liquids</topic><topic>Male</topic><topic>Mass spectrometry</topic><topic>molecular imprinting</topic><topic>polymers</topic><topic>Rats</topic><topic>solid phase extraction</topic><topic>Solid phases</topic><topic>sorption</topic><topic>tandem mass spectrometry</topic><topic>Tandem Mass Spectrometry - methods</topic><topic>Thiazoles - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petrikovics, Ilona</creatorcontrib><creatorcontrib>Yu, Jorn C.C.</creatorcontrib><creatorcontrib>Thompson, David E.</creatorcontrib><creatorcontrib>Jayanna, Prashanth</creatorcontrib><creatorcontrib>Logue, Brian A.</creatorcontrib><creatorcontrib>Nasr, Jessica</creatorcontrib><creatorcontrib>Bhandari, Raj K.</creatorcontrib><creatorcontrib>Baskin, Steven I.</creatorcontrib><creatorcontrib>Rockwood, Gary</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chromatography. 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B, Analytical technologies in the biomedical and life sciences</jtitle><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>891-892</volume><spage>81</spage><epage>84</epage><pages>81-84</pages><issn>1570-0232</issn><eissn>1873-376X</eissn><abstract>► ATCA persistence was determined after injecting it directly to the blood stream. ► ATCA concentration in blood decreased to half within 2.5h in the rat system. ► After the initial loss, ATCA level stayed constant (700ng/ml) over 48h. ► Endogenous ATCA level in blood was found 141ng/ml. ► The role of ATCA as a biomarker for CN exposure needs more future investigations.
2-Aminothiazoline-4-carboxylic acid (ATCA) was intravenously injected to rats in order to investigate its plasma distribution. ATCA was extracted from plasma samples by solid phase extraction (SPE) and molecularly imprinted polymer stir bar sorption extraction (MIP-SBSE). Detection and quantification of ATCA were achieved by using liquid chromatography–tandem mass spectrometry (LC–MS/MS). It was found that the intravenously injected ATCA concentration quickly decreased to half within 2.5h in the rat system. However, after 2.5h, the concentration of ATCA in plasma stayed constant at least 5 folds above the endogenous ATCA level for more then 48h. This finding can be used for evaluating ATCA's diagnostic and forensic value as a biomarker for cyanide exposure.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>22386362</pmid><doi>10.1016/j.jchromb.2012.01.024</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 1570-0232 1873-376X |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | 2-Aminothiazoline-4-carboxylic acid (ATCA) Animals biomarkers Chromatography Chromatography, Liquid - methods Cyanide exposure cyanides Diagnostic biomarker Diagnostic systems Extraction Forensic biomarker forensic sciences Imprinted polymers intravenous injection LC–MS/MS liquid chromatography Liquids Male Mass spectrometry molecular imprinting polymers Rats solid phase extraction Solid phases sorption tandem mass spectrometry Tandem Mass Spectrometry - methods Thiazoles - blood |
| title | Plasma persistence of 2-aminothiazoline-4-carboxylic acid in rat system determined by liquid chromatography tandem mass spectrometry |
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