Fluid management in diabetic-acidosis--Ringer's lactate versus normal saline: a randomized controlled trial

To determine if Ringer's lactate is superior to 0.9% sodium chloride solution for resolution of acidosis in the management of diabetic ketoacidosis (DKA). Parallel double blind randomized controlled trial. Patients presenting with DKA at Kalafong and Steve Biko Academic hospitals were recruited...

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Bibliographic Details
Published in:QJM : An International Journal of Medicine 2012-04, Vol.105 (4), p.337-343
Main Authors: Van Zyl, D G, Rheeder, P, Delport, E
Format: Article
Language:English
Subjects:
Adult
Blood Glucose - metabolism
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetic Ketoacidosis - blood
Diabetic Ketoacidosis - etiology
Diabetic Ketoacidosis - therapy
Double-Blind Method
Female
Fluid Therapy - methods
Humans
Hydrogen-Ion Concentration
Isotonic Solutions - therapeutic use
Male
Middle Aged
Sodium Chloride - therapeutic use
Treatment Outcome
Young Adult
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Summary:To determine if Ringer's lactate is superior to 0.9% sodium chloride solution for resolution of acidosis in the management of diabetic ketoacidosis (DKA). Parallel double blind randomized controlled trial. Patients presenting with DKA at Kalafong and Steve Biko Academic hospitals were recruited for inclusion in this study if they were >18 years of age, had a venous pH >6.9 and ≤7.2, a blood glucose of >13 mmol/l and had urine ketones of ≥2+. All patients had to be alert enough to give informed consent and should have received
ISSN:1460-2725
1460-2393
DOI:10.1093/qjmed/hcr226