Effect of levetiracetam monotherapy on background EEG activity and cognition in drug-naïve epilepsy patients

Highlights ► We evaluated the effect of LEV on background EEG and cognition in epilepsy patients. ► LEV decreases slow frequency power and increases fast frequency power. ► LEV causes improvement in diverse neuropsychological tests. ► Some EEG changes across LEV therapy were correlated with change i...

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Bibliographic Details
Published in:Clinical neurophysiology 2012-05, Vol.123 (5), p.883-891
Main Authors: Cho, Jounhong Ryan, Koo, Dae Lim, Joo, Eun Yeon, Yoon, So Mi, Ju, Eunji, Lee, James, Kim, Dae Young, Hong, Seung Bong
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anticonvulsants - pharmacology
Anticonvulsants - therapeutic use
Antiepileptic drugs
Biological and medical sciences
Brain Mapping
Brain Waves - drug effects
Cognition - drug effects
Cognitive function
EEG
Electrodiagnosis. Electric activity recording
Electroencephalography
Epilepsy - drug therapy
Epilepsy - physiopathology
Executive Function - drug effects
Female
Follow-Up Studies
Fourier Analysis
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Investigative techniques, diagnostic techniques (general aspects)
Levetiracetam
Linear Models
Male
Medical sciences
Middle Aged
Nervous system
Nervous system (semeiology, syndromes)
Neurology
Neuropsychological Tests
Piracetam - analogs & derivatives
Piracetam - pharmacology
Piracetam - therapeutic use
Quantitative analysis
Retrospective Studies
Verbal Learning - drug effects
Young Adult
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Summary:Highlights ► We evaluated the effect of LEV on background EEG and cognition in epilepsy patients. ► LEV decreases slow frequency power and increases fast frequency power. ► LEV causes improvement in diverse neuropsychological tests. ► Some EEG changes across LEV therapy were correlated with change in cognitive tests.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2011.09.012