Facilitating the mineralization of oligo(poly(ethylene glycol) fumarate) hydrogel by incorporation of hydroxyapatite nanoparticles

Exploring strategies to induce the mineralization of hydrogels is an important step toward the development of hydrogel‐based materials for bone regeneration. In the current study, the effect of incorporating hydroxyapatite (HA) nanoparticles on the mineralization capacity of an inert poly(ethylene g...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2012-05, Vol.100A (5), p.1316-1323
Main Authors: Nejadnik, M. Reza, Mikos, Antonios G., Jansen, John A., Leeuwenburgh, Sander C. G.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Body Fluids - chemistry
bone regeneration
Calcium - metabolism
Cattle
Cell physiology
composite
Durapatite - chemistry
Fumarates - chemistry
Fundamental and applied biological sciences. Psychology
Gelatin - chemistry
hydrogel
Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry
hydroxyapatite nanoparticles
Medical sciences
mineralization
Mineralization, calcification
Minerals - chemistry
Molecular and cellular biology
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Orthopedic surgery
Polyethylene Glycols - chemistry
Spectroscopy, Fourier Transform Infrared
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
Time Factors
X-Ray Diffraction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Exploring strategies to induce the mineralization of hydrogels is an important step toward the development of hydrogel‐based materials for bone regeneration. In the current study, the effect of incorporating hydroxyapatite (HA) nanoparticles on the mineralization capacity of an inert poly(ethylene glycol) (PEG)‐based hydrogel was investigated. HA nanoparticles were either directly loaded into oligo(poly(ethylene glycol) fumarate) (OPF) hydrogel or loaded into commonly used gelatin microsphere porogens that were subsequently integrated in the OPF matrix. Mineralization of composites after immersion of the samples in simulated body fluid up to 28 days was assessed. In contrast to the blank OPF hydrogel, the HA‐containing constructs strongly mineralized such that the average rate of calcium uptake by the material was enhanced by orders of magnitude. The mineral formed was observed to be apatitic and needle shaped. The presented method allows modification of inert PEG‐based hydrogels into bioactive biomaterials for applications in bone regeneration. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 2012.
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.34071