Effects of Non‐Surgical Periodontal Treatment on Clinical Response, Serum Inflammatory Parameters, and Metabolic Control in Patients With Type 2 Diabetes: A Randomized Study

• Published in: Journal of periodontology (1970) 2012-04, Vol.83 (4), p.435-443
• Main Authors: Chen, Lei, Luo, Gang, Xuan, Dongying, Wei, Bihong, Liu, Fang, Li, Jing, Zhang, Jincai
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Blood Glucose - analysis; C-Reactive Protein - analysis; Cholesterol - blood; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Chronic Periodontitis - blood; Chronic Periodontitis - therapy; C‐reactive protein; Dental Prophylaxis; Dental Scaling - methods; Dentistry; diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - immunology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Fasting; Female; Follow-Up Studies; Glycated Hemoglobin A - analysis; Humans; Inflammation Mediators - blood; Male; Medical sciences; Middle Aged; Non tumoral diseases; Otorhinolaryngology. Stomatology; periodontitis; Root Planing - methods; Subgingival Curettage - methods; Treatment Outcome; Triglycerides - blood; Tumor Necrosis Factor-alpha - blood; tumor necrosis factor‐alpha
• ISSN: 0022-3492; 1943-3670
• DOI: 10.1902/jop.2011.110327

Background: Scientific evidence on the effects of chronic periodontitis on diabetes mellitus remains inadequate and inconclusive. This intervention study is designed to evaluate the effects of periodontal treatment on clinical response, systemic inflammatory parameters, and metabolic control in patients with Type 2 diabetes. Methods: A total of 134 patients were randomly allocated into two treatment groups and one control group. Treatment group 1 underwent non‐surgical periodontal treatment at baseline and additional subgingival debridement at the 3‐month follow‐up. Patients in treatment group 2 received non‐surgical periodontal treatment and supragingival prophylaxis at the 3‐month follow‐up, and those in the control group received no intervention throughout the study. All participants were reexamined at 1.5, 3, and 6 months after initial treatment. At each visit, clinical periodontal examinations were conducted and blood samples were taken to evaluate high‐sensitivity C‐reactive protein (hsCRP), tumor necrosis factor‐α (TNF‐α), glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), and lipid profiles. Results: Both treatment groups had a significantly lower hsCRP level after periodontal therapy (P