In vivo efficacy of the diuretic agent ethacrynic acid against multiple myeloma

Abstract It was recently confirmed that the diuretic agent ethacrynic acid (EA) inhibits Wnt/beta catenin signaling in myeloma. This study investigated the antitumor effect of EA in vivo in a murine myeloma model. In vivo, tumor growth was significantly reduced and overall survival significantly pro...

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Bibliographic Details
Published in:Leukemia research 2012-05, Vol.36 (5), p.598-600
Main Authors: Kim, Young, Gast, Sanna-Marie, Endo, Tomoyuki, Lu, Desheng, Carson, Dennis, Schmidt-Wolf, Ingo G.H
Format: Article
Language:English
Subjects:
Animal models
Animals
Antitumor activity
Beta catenin
beta Catenin - physiology
catenin
Cell Line, Tumor
Disease Models, Animal
Diuretics
Diuretics - therapeutic use
Drug Therapy, Combination
Drugs
Ethacrynic acid
Ethacrynic Acid - administration & dosage
Ethacrynic Acid - therapeutic use
Hematology, Oncology and Palliative Medicine
Humans
Lenalidomide
Lymphoma
Mice
Mice, Inbred BALB C
Multiple myeloma
Multiple Myeloma - drug therapy
Multiple Myeloma - mortality
Myeloma
Signal transduction
Survival
Thalidomide - administration & dosage
Thalidomide - analogs & derivatives
Tumors
Wnt pathway
Wnt protein
Wnt Signaling Pathway
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Summary:Abstract It was recently confirmed that the diuretic agent ethacrynic acid (EA) inhibits Wnt/beta catenin signaling in myeloma. This study investigated the antitumor effect of EA in vivo in a murine myeloma model. In vivo, tumor growth was significantly reduced and overall survival significantly prolonged in mice treated with EA as compared to untreated mice. Interestingly, this effect was higher as compared to the effect by lenalidomide, a commonly used drug against myeloma. These results reveal a significant in vivo effect by EA against myeloma.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2012.01.025