Experimental infection of rabbits (Oryctolagus cuniculus) with Brucella suis biovar 1 isolated from wild hares (Lepus europaeus)

Brucella suis biovar 1 is the causative agent of brucellosis in several domestic and wild animals and it is a common agent of human brucellosis. European hares (Lepus europaeus) have been shown to be infected by B. suis biovar 1 and the transmission to other animals has been suggested. In this work,...

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Bibliographic Details
Published in:Veterinary microbiology 2012-05, Vol.156 (3-4), p.439-442
Main Authors: Fort, Marcelo, Baldone, Valeria, Fuchs, Lumila, Giménez, Hugo, Rojas, María, Breccia, Javier D., Oyhenart, Jorge
Format: Article
Language:English
Subjects:
AMOS PCR
Animals
Animals, Wild - microbiology
Bacterial diseases
Bacteriology
Biological and medical sciences
Brucella suis
Brucella suis - pathogenicity
Brucellosis
Brucellosis - pathology
Brucellosis - veterinary
Female
Fundamental and applied biological sciences. Psychology
Hares - microbiology
Horizontal transmission
Human bacterial diseases
Infectious diseases
Kidney - microbiology
Kidney - pathology
Lepus europaeus
Liver - microbiology
Liver - pathology
Male
Medical sciences
Microbiology
Miscellaneous
Oryctolagus cuniculus
Pregnancy
Pregnancy Complications, Infectious - microbiology
Pregnancy Complications, Infectious - veterinary
Rabbits - microbiology
Spleen - microbiology
Spleen - pathology
Wildlife
Zoonosis
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Summary:Brucella suis biovar 1 is the causative agent of brucellosis in several domestic and wild animals and it is a common agent of human brucellosis. European hares (Lepus europaeus) have been shown to be infected by B. suis biovar 1 and the transmission to other animals has been suggested. In this work, experimental rabbits (Cuniculus orictolagus) were infected with B. suis biovar 1 isolated from wild hares. Infected rabbits showed high serological response in 2 weeks after discharge and typical granulomatous lesions (2mm diameter) were found in liver, spleen and kidneys after 50 days. B. suis biovar 1 was cultured from the lesion of the organs mentioned above as well as from urine, placenta and fetuses. These data suggest that hares are a potential source for horizontal transmission of B. suis biovar 1 to other mammalians.
ISSN:0378-1135
1873-2542
DOI:10.1016/j.vetmic.2011.11.006