Body composition in children with type 1 diabetes in the first year after diagnosis: relationship to glycaemic control and cardiovascular risk

• Published in: Archives of disease in childhood 2012-04, Vol.97 (4), p.312-315
• Main Authors: Davis, Nikki L, Bursell, James D H, Evans, William D, Warner, Justin T, Gregory, John W
• Format: Article
• Language: English
• Subjects: Absorptiometry, Photon; Adolescent; Anthropometry - methods; Biological and medical sciences; Blood Glucose - metabolism; Blood pressure; Blood Pressure - physiology; Body composition; Body Composition - physiology; Body fat; Body Mass Index; body weight; Cardiovascular disease; Care and treatment; Case-Control Studies; Causes of; Child; Child, Preschool; Children; Children & youth; Cholesterol; Diabetes; diabetes mellitus; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - drug therapy; Diabetes Mellitus, Type 1 - physiopathology; Diabetes. Impaired glucose tolerance; Diabetic Angiopathies - physiopathology; Diagnosis; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Gender; General aspects; Glycated Hemoglobin A - metabolism; Health aspects; Health risks; Humans; Hypoglycemic Agents - therapeutic use; Infant; Infant, Newborn; insulin; Insulin - therapeutic use; Insulin resistance; Lipids - blood; Male; Measurement; Medical sciences; Miscellaneous; Obesity; Prevention and actions; Proteins; Puberty; Public health. Hygiene; Public health. Hygiene-occupational medicine; Sensitivity; Sex Characteristics; Thinness - blood; Thinness - etiology; Thinness - physiopathology; Type 1 diabetes
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/archdischild-2011-300626

Introduction Rapid weight gain is often observed following initiation of insulin therapy in children with type 1 diabetes mellitus (T1DM) and girls are particularly at risk of becoming overweight. The authors evaluated body composition changes in children during the first year after diagnosis and related this to markers of cardiovascular risk. Methods Body mass index (BMI) and body composition measured by whole body dual energy x-ray absorptiometry (DEXA) were assessed in 30 patients (18 boys) with T1DM 3–10 days after diagnosis, 6 weeks later and at 1 year, and on two occasions 1 year apart in 14 controls (8 boys). Cardiovascular risk markers were assessed in T1DM subjects at 1 year. Results T1DM subjects had lower BMI SD scores (SDS) at diagnosis than controls (mean (SD) BMI SDS −0.67 (1.34) vs 0.20 (1.14), p