Age-Related Peculiarities in Steroid Hormone Secretion and Behavior in Prenatally Stressed Female Rats in Novel Environment

We studied the effects of immobilization of female rat during days 15–18 of pregnancy on the behavior in novel environment (open field test) and blood level of steroid hormones in their female offspring depending on the cycle phase and age. The rats were tested at the age of 3, 12, and 24 months. Lo...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2011-08, Vol.151 (4), p.392-395
Main Authors: Pivina, S. G., Shamolina, T. S., Ordyan, N. E.
Format: Article
Language:English
Subjects:
Aging - blood
Animals
Behavior, Animal
Biomedical and Life Sciences
Biomedicine
Cell Biology
Estradiol - metabolism
Estrogen
Female
Internal Medicine
Laboratory Medicine
Maternal Exposure
Pathology
Pregnancy
Progesterone
Progesterone - metabolism
Rats
Rats, Wistar
Stress, Physiological
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Summary:We studied the effects of immobilization of female rat during days 15–18 of pregnancy on the behavior in novel environment (open field test) and blood level of steroid hormones in their female offspring depending on the cycle phase and age. The rats were tested at the age of 3, 12, and 24 months. Locomotor and exploratory activity and anxiety of control rats depended on the phase of estrous cycle. Age-related changes in the studied parameters were noted: locomotor and exploratory activity decreased and anxiety increased against the background of reduced secretion of the main ovarian hormones with age. In addition, blood estradiol level and behavior in novel environment virtually did not depend on age and estrous cycle phase in prenatally stressed females. Our fi ndings suggest that maternal stress has a modulatory effect on relationship between behavioral type and estrous cycle stage, as well as on age-related pattern of behavioral reactions.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-011-1339-3