Circulating high-mobility group box 1 and cardiovascular mortality in unstable angina and non-ST-segment elevation myocardial infarction

Highlights ► HMGB1 is a damage-associated molecular pattern molecule. ► We evaluated the prognostic value of HMGB1 on admission in 258 UA/NSTEMI patients. ► Increased HMGB1 was significantly associated with cardiovascular mortality rate. ► Increased HMGB1 was an independent predictor of cardiovascul...

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Bibliographic Details
Published in:Atherosclerosis 2012-04, Vol.221 (2), p.490-495
Main Authors: Hashimoto, Tousei, Ishii, Junnichi, Kitagawa, Fumihiko, Yamada, Shingo, Hattori, Kousuke, Okumura, Masanori, Naruse, Hiroyuki, Motoyama, Sadako, Matsui, Shigeru, Tanaka, Ikuko, Izawa, Hideo, Maruyama, Ikuro, Nomura, Masanori, Ozaki, Yukio
Format: Article
Language:English
Subjects:
Aged
Angina, Unstable - blood
Angina, Unstable - diagnosis
Angina, Unstable - mortality
atherosclerosis
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Biomarkers - blood
Blood and lymphatic vessels
C-reactive protein
C-Reactive Protein - analysis
Cardiac troponin I
Cardiology. Vascular system
Cardiovascular
Cardiovascular mortality
chest
Chi-Square Distribution
Coronary Angiography
Female
High-mobility group box 1
High-sensitivity C-reactive protein
HMGB1 Protein - blood
Hospital Mortality
Hospitalization
Humans
Japan - epidemiology
Kaplan-Meier Estimate
Male
Medical sciences
Middle Aged
mortality
myocardial infarction
Myocardial Infarction - blood
Myocardial Infarction - diagnosis
Myocardial Infarction - mortality
Natriuretic Peptide, Brain - blood
natriuretic peptides
Neurology
pathophysiology
patients
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Prospective Studies
regression analysis
relative risk
Risk Assessment
Risk Factors
Time Factors
Troponin I - blood
Unstable angina and non-ST-segment elevation myocardial infarction
Up-Regulation
Vascular diseases and vascular malformations of the nervous system
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Summary:Highlights ► HMGB1 is a damage-associated molecular pattern molecule. ► We evaluated the prognostic value of HMGB1 on admission in 258 UA/NSTEMI patients. ► Increased HMGB1 was significantly associated with cardiovascular mortality rate. ► Increased HMGB1 was an independent predictor of cardiovascular mortality. ► Measurements of HMGB1 improve the early risk stratification of UA/NSTEMI patients.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2012.01.040