Peptides from the Pituitary Gland and Cortex Stimulate Differentiation of Polypotent Embryonic Tissue

We studied the effects of synthetic peptides from the pituitary gland and brain cortex on differentiation of polypotent ectodermal tissue of the early gastrula of Xenopus laevis. It was shown that the pituitary gland peptide stimulates differentiation of polypotent tissue into epidermis and nerve ti...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2011-08, Vol.151 (4), p.530-531
Main Authors: Lin’kova, N. S., Trofimov, A. V., Dudkov, A. V.
Format: Article
Language:English
Subjects:
Amphibians
Animals
Biomedical and Life Sciences
Biomedicine
Brain
Cell Biology
Cell Differentiation - drug effects
Cerebral Cortex - chemistry
Cortex
Differentiation
Embryos
Epidermis
Internal Medicine
Laboratory Medicine
Nerves
Neurodegenerative diseases
Pathology
Peptides
Peptides - pharmacology
Pituitary
Pituitary Gland - chemistry
synthetic peptides
Xenopus laevis
Xenopus laevis - embryology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied the effects of synthetic peptides from the pituitary gland and brain cortex on differentiation of polypotent ectodermal tissue of the early gastrula of Xenopus laevis. It was shown that the pituitary gland peptide stimulates differentiation of polypotent tissue into epidermis and nerve tissue, while brain cortex peptide induces the development of mesenchyma and epidermis. Differentiation of polypotent tissue under the effect of the peptide is a mechanism of their geroprotective effect and suggests that they are promising as preparations for the treatment of neurodegenerative diseases.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-011-1373-1