A comparison of epidermal growth factor receptor expression in malignant peritoneal and pleural mesothelioma

An evaluation of epidermal growth factor receptor (EGFR) phenotypic expression in malignant pleural and peritoneal mesothelioma was undertaken, using immunohistochemical (IHC) and fluorescence in situ hybridization (FISH) analysis. Thirty‐eight malignant mesothelioma (MM) specimens were subjected to...

Full description

Saved in:
Bibliographic Details
Published in:Pathology international 2012-04, Vol.62 (4), p.226-231
Main Authors: Enomoto, Yasunori, Kasai, Takahiko, Takeda, Maiko, Takano, Masato, Morita, Kouhei, Kadota, Eiji, Iizuka, Norishige, Maruyama, Hiroshi, Haratake, Joji, Kojima, Yu, Ikeda, Naoya, Nonomura, Akitaka
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - metabolism
DNA, Neoplasm - analysis
epidermal growth factor receptor
Female
FISH
gene copy number gain
Gene Dosage
Gene Expression Regulation, Neoplastic
Genetic Markers
Humans
immunohistochemistry
In Situ Hybridization, Fluorescence
Male
malignant mesothelioma
Mesothelioma - genetics
Mesothelioma - metabolism
Mesothelioma - pathology
Middle Aged
Peritoneal Neoplasms - genetics
Peritoneal Neoplasms - metabolism
Peritoneal Neoplasms - pathology
Pleural Neoplasms - genetics
Pleural Neoplasms - metabolism
Pleural Neoplasms - pathology
Receptor, Epidermal Growth Factor - genetics
Receptor, Epidermal Growth Factor - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An evaluation of epidermal growth factor receptor (EGFR) phenotypic expression in malignant pleural and peritoneal mesothelioma was undertaken, using immunohistochemical (IHC) and fluorescence in situ hybridization (FISH) analysis. Thirty‐eight malignant mesothelioma (MM) specimens were subjected to IHC staining and FISH to evaluate the expression of EGFR protein and gene status. Overall positive IHC reaction was detected in 20/38 (53%) cases, in 11/22 (50%) pleural MM, and in 9/16 (56%) peritoneal MM. Our study confirmed that EGFR membranous expression is a common feature in MM, but not in benign mesothelial lesion. Thirty‐seven cases did not show a gene copy number gain. Only one case showed a copy number gain. The protein overexpression of EGFR was not related to a gene copy number gain.
ISSN:1320-5463
1440-1827
DOI:10.1111/j.1440-1827.2011.02778.x