Patients with CD36 Deficiency Are Associated with Enhanced Atherosclerotic Cardiovascular Diseases

Aim: The clustering of dyslipidemia, impaired glucose tolerance and hypertension increases the morbidity and mortality from cardiovascular events. A class B scavenger receptor, CD36, is a receptor for oxidized LDL and a transporter of long-chain fatty acids. Because of the impaired uptake of oxidize...

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Published in:Journal of Atherosclerosis and Thrombosis 2012, Vol.19(3), pp.263-275
Main Authors: Yuasa-Kawase, Miyako, Masuda, Daisaku, Yamashita, Taiji, Kawase, Ryota, Nakaoka, Hajime, Inagaki, Miwako, Nakatani, Kazuhiro, Tsubakio-Yamamoto, Kazumi, Ohama, Tohru, Matsuyama, Akifumi, Nishida, Makoto, Ishigami, Masato, Kawamoto, Toshiharu, Komuro, Issei, Yamashita, Shizuya
Format: Article
Language:English
Subjects:
Aged
Atherosclerosis - etiology
Atherosclerosis - metabolism
Atherosclerotic cardiovascular disease
Blood Platelets - metabolism
Cardiovascular Diseases - etiology
Cardiovascular Diseases - metabolism
Case-Control Studies
CD36 Antigens - deficiency
CD36 deficiency
Female
Flow Cytometry
Humans
Insulin resistance
Long-chain fatty acid transporter
Male
Metabolic syndrome
Monocytes - metabolism
Risk Factors
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Summary:Aim: The clustering of dyslipidemia, impaired glucose tolerance and hypertension increases the morbidity and mortality from cardiovascular events. A class B scavenger receptor, CD36, is a receptor for oxidized LDL and a transporter of long-chain fatty acids. Because of the impaired uptake of oxidized LDL in CD36-deficient macrophages and from the results of CD36 knockout mice, CD36 deficiency (CD36-D) was supposed to be associated with reduced risks for coronary artery disease (CAD); however, CD36-D patients are often accompanied by a clustering of coronary risk factors. The current study aimed to investigate the morbidity and severity of cardiovascular diseases in CD36-D patients. Methods: By screening for CD36 antigen on platelets and monocytes using FACS or the absent myocardial accumulation of 123I-BMIPP by scintigraphy, 40 patients with type I CD36-D were collected, the morbidity of CAD and their features of atherosclerotic cardiovascular diseases were observed. Screening for CD36-D in both CAD patients (n =319) and healthy subjects (n =1,239) were underwent. Results: The morbidity of CAD was significantly higher in CD36-D patients than in the general population; 50% of patients (20 out of 40) had CAD identified by BMIPP scintigraphy and 37.5% (3 out of 8) by FACS screening, respectively. Three representative CD36-D cases demonstrated severe CAD and atherosclerosis. The frequency of CD36-D was three times higher in CAD patients than in healthy subjects (0.9% vs 0.3%, p
ISSN:1340-3478
1880-3873
DOI:10.5551/jat.10603