Threefold Exposure to Moderate Hypobaric Hypoxia Decreases the Expression of Cu,Zn-Superoxide Dismutase in Some Regions of Rat Hippocampus

The effect of moderate hypobaric hypoxia on the expression of a peptide antioxidant Cu,Zn-superoxide dismutase in rat hippocampal neurons was evaluated in an immunocytochemical study. The expression of Cu,Zn-superoxide dismutase decreased significantly in the dorsal hippocampus (CA1 and CA2) and ten...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2011-07, Vol.151 (3), p.301-304
Main Authors: Stroev, S. A., Tyul’kova, E. I., Pelto-Huikko, M. T., Samoilov, M. O.
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Biomedical and Life Sciences
Biomedicine
Brain
CA1 Region, Hippocampal - enzymology
CA3 Region, Hippocampal - enzymology
Cell Biology
Dentate gyrus
Dentate Gyrus - enzymology
Hippocampus
Hippocampus - enzymology
Hypoxia
Hypoxia - enzymology
Internal Medicine
Laboratory Medicine
Male
Neurons
Neurons - enzymology
Oxidative Stress
Pathology
Rats
Rats, Wistar
Superoxide
Superoxide Dismutase - metabolism
Zinc compounds
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of moderate hypobaric hypoxia on the expression of a peptide antioxidant Cu,Zn-superoxide dismutase in rat hippocampal neurons was evaluated in an immunocytochemical study. The expression of Cu,Zn-superoxide dismutase decreased significantly in the dorsal hippocampus (CA1 and CA2) and tended to decrease in ventral regions (CA3 and dentate gyrus) by the 24th hour after 3-fold exposure to hypoxia.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-011-1314-z